3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 179688-53-0 |
| Product name | 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of the anticancer drug pemetrexed | Used in multistep organic synthesis to construct the quinazoline core structure, followed by functional group transformations and coupling reactions to yield the target drug molecule |
Manufacturing Quality Control of 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
| Test Item | Common Test Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the color, form (e.g., white to nearly white crystalline powder), and check for foreign matter or moisture absorption. |
| HPLC (High-Performance Liquid Chromatography) | Identify by comparing retention time with that of a reference standard to ensure consistency in the main component's peak position. | |
| Determination of Content | HPLC | Use a UV detector at a specific wavelength (e.g., 254 nm or optimized according to the maximum absorption wavelength) to determine the content of the main component using an external standard method or area normalization method. |
| Related Substances (Impurities) | HPLC | Use gradient elution or isocratic elution to separate and quantify each impurity peak. Typically, the limit of impurities is calculated using self-reference or external standard methods (e.g., single impurity ≤ 0.5%, total impurities ≤ 1.0%). |
| Dry Loss | Drying Method (Constant Weight Method at 105°C) | Weigh the sample in a constant weight dish, dry at 105°C until constant weight, and calculate the percentage of mass loss to control moisture and volatile substances. |
| Residual Solvents | Gas Chromatography (GC), Headspace Sampling | According to ICH Q3C guidelines, detect residual organic solvents (e.g., ethyl acetate, methanol, DMF) from the synthesis process. Use a capillary column for separation and quantification. |
| Melting Point | Capillary Melting Point Determination | Determine the melting range from initial to complete melting, which serves as a physical constant for auxiliary identification and purity assessment. |
| pH Value (If Solution) | pH Meter Measurement | If prepared as a solution (e.g., injection or intermediate solution), measure its pH value to ensure it falls within the specified range (e.g., 4.0–6.0). |
| Heavy Metals | Heavy Metal Test Method from the Chinese Pharmacopoeia | Use the thioacetamide method or ICP-MS to control the total amount of harmful metals (e.g., lead, cadmium, mercury, arsenic) to not exceed 10 ppm (parts per million). |
| Residue on Ignition | High-Temperature Ashing Method | Heat the sample at high temperature (700–800°C) and weigh the residue to determine the amount of inorganic impurities. Usually, the requirement is ≤ 0.1%. |
Technical Specifications of 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 192–196°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
Safety Information of 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate
Industrial 3,4-Dihydro-7-methoxy-4-oxoquinazolin-6-yl acetate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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