1-N-BOC-4-BROMOPIPERIDINE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 180695-79-8 |
| Product name | 1-N-BOC-4-BROMOPIPERIDINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1-N-BOC-4-BROMOPIPERIDINE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1-N-BOC-4-BROMOPIPERIDINE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1-N-BOC-4-BROMOPIPERIDINE
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Building block for drug molecules, used in synthesizing small-molecule inhibitors (e.g., kinase inhibitors) or active pharmaceutical ingredients (APIs) | Organic synthesis intermediate, typically incorporated at a late stage of multi-step synthesis to introduce the piperidine ring structure |
| Research & Development | Chemical reagent for drug discovery, lead compound optimization, and structure–activity relationship (SAR) studies | Synthesized at laboratory scale to construct compound libraries containing functionalized piperidine motifs |
| Fine Chemicals | Key raw material for synthesizing more complex fine chemicals and custom intermediates | Used as a reactant in further functional group transformations, such as amine alkylation or nucleophilic substitution reactions |
Manufacturing Quality Control of 1-N-BOC-4-BROMOPIPERIDINE
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Purity | High-Performance Liquid Chromatography (HPLC) | Uses a reversed-phase C18 column with a UV detector (e.g., 210–220 nm), calculating the purity of the main component by area normalization or external standard method. Suitable for quantitative analysis of the main component and related substances. |
| Related Substances/Impurities | HPLC (Gradient Elution) | Separates potential process impurities and degradation products using a gradient elution program, with LC-MS for structural identification. Impurity limits are typically set (e.g., single impurity ≤ 0.5%, total impurities ≤ 1.0%). |
| Moisture | Karl Fischer Titration | Measures water content using volumetric or coulometric methods, controlling residual moisture in active pharmaceutical ingredients (usually required < 0.5%), to avoid affecting stability or reactivity. |
| Residual Solvents | Gas Chromatography (GC, headspace injection) | Quantifies common organic solvent residues (e.g., ethyl acetate, dichloromethane, methanol) according to ICH Q3C guidelines, using capillary columns (e.g., DB-624) and FID detectors. |
| Structural Confirmation | Proton Nuclear Magnetic Resonance (¹H NMR) | Determines chemical shifts, coupling constants, and integration ratios of hydrogen atoms in deuterated solvents (e.g., CDCl₃), confirming molecular structure consistent with the target compound. |
| Fourier Transform Infrared Spectroscopy (FT-IR) | Identifies characteristic functional group absorption peaks (e.g., Boc group ~1700 cm⁻¹ carbonyl peak, C-Br bond ~500–600 cm⁻¹) to assist in structural verification. | |
| Mass Spectrometry (ESI-MS or EI-MS) | Measures molecular ion peaks ([M+H]⁺ or [M+Na]⁺), confirming molecular weight (theoretical value: C₁₀H₁₈BrNO₂ = 264.05 / 286.03 [M+Na]⁺), assisting in structural identification. | |
| Melting Point | Capillary Melting Point Apparatus | Measures the melting range (if applicable) as a physical constant for identification (note: some tert-butyl esters may be oily and have no clear melting point). |
| Heavy Metals | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) or Atomic Absorption Spectroscopy (AAS) | Tests for heavy metal impurities (lead, cadmium, arsenic, mercury, copper) according to pharmacopoeia general rules, ensuring compliance with ICH Q3D limits (typically < 10–20 ppm). |
| Specific Rotation (if chiral) | Polarimeter | If there are chiral centers and enantiomeric purity needs to be controlled, specific rotation is measured and compared with a reference standard; alternatively, chiral HPLC can directly separate enantiomers. |
| pH Value (in solution state) | pH Meter | Determine the pH of the sample dissolved in an appropriate solvent (e.g., water/methanol mixture) to assess its acidity or alkalinity, indirectly reflecting the presence of acidic or basic impurities. |
Technical Specifications of 1-N-BOC-4-BROMOPIPERIDINE
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (by LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 65–69°C |
| Identification (NMR) | Conforms to reference spectrum |
| Optical Rotation | [α]D20 = -15.0° to -19.0° (c=1, CHCl3) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1-N-BOC-4-BROMOPIPERIDINE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1-N-BOC-4-BROMOPIPERIDINE
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Industrial 1-N-BOC-4-BROMOPIPERIDINE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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