3-BROMOIMIDAZO[1,2-B]PYRIDAZINE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 18087-73-5 |
| Product name | 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Serves as a synthetic intermediate for preparing kinase inhibitors (e.g., ALK and JAK inhibitors) | Introduces bromine at specific sites via Suzuki coupling, nucleophilic substitution, or transition-metal-catalyzed cross-coupling to construct the active molecular scaffold |
| Agrochemicals | Used to synthesize biologically active heterocyclic compounds with potential application in insecticide or fungicide development | Acts as a key building block in heterocycle modification and functional group transformation to optimize molecular activity against target organisms |
| Organic Synthesis | A brominated nitrogen-containing heterocycle employed to construct complex molecular architectures | Undergoes metalation (e.g., lithiation, magnesiation) or transition-metal-catalyzed coupling (e.g., Negishi, Stille reactions) via the C–Br bond |
Manufacturing Quality Control of 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Purity (Assay) | High-Performance Liquid Chromatography (HPLC) | Uses a C18 reversed-phase column with gradient elution employing water-acetonitrile or methanol as mobile phase. The main peak is detected by UV detector (typically at 254 nm). Purity is calculated using external standard or area normalization method, allowing simultaneous detection of related impurities. |
| Impurity Profile | HPLC-UV / HPLC-MS | After HPLC separation, impurities are identified using mass spectrometry (ESI or APCI ion sources), enabling structural identification of unknown impurities such as unreacted starting materials, by-products (e.g., dibrominated compounds), and degradation products, in compliance with ICH Q3B guidelines. |
| Residual Solvents | Gas Chromatography (GC-FID / GC-MS) | Headspace or direct injection is used with DB-624 or HP-INNOWAX columns to separate and detect common organic solvents such as ethanol, acetone, DMF, and acetonitrile. Results are evaluated against ICH Q3C permissible limits. |
| Water Content | Karl Fischer Titration (KF) | Employs coulometric or volumetric Karl Fischer reagents to accurately determine trace moisture content, ensuring compliance with pharmacopeial requirements for active pharmaceutical ingredients (typically ≤0.5%). |
| Melting Point | Melting Point Apparatus | Determined using a digital melting point instrument to measure the melting temperature range, serving as a preliminary identification tool and for batch-to-batch consistency control. Typical range is approximately 120–135°C (literature value; requires experimental calibration). |
| Chlorides/Halogen Residues | Ion Chromatography (IC) or Oxygen Flask Combustion + Ion-Selective Electrode | Sample is combusted in an oxygen flask and absorbed; bromide ion (Br⁻) content is then determined by ion chromatography or bromide ion-selective electrode to ensure no excessive halogen impurities are present. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After acid digestion, levels of heavy metals such as lead, cadmium, mercury, and arsenic are measured by AAS or ICP-MS, meeting ICH Q3D or pharmacopeial limits (e.g., ≤10 ppm). |
| UV-Visible Absorption Spectrum | UV-Vis Spectrophotometer | Measures characteristic absorption peaks in the 200–400 nm wavelength range (e.g., λmax ≈ 260–280 nm), used for qualitative confirmation and rapid concentration estimation (requires calibration with reference standard). |
| Nitrogen Content (Elemental Analysis) | Elemental Analyzer (CHNS/O) | Determines the content of C, H, N, and S by combustion oxidation method. Comparison with theoretical values verifies the correctness of molecular structure, particularly useful for structural confirmation of new synthetic routes. |
| Crystal Form (if applicable) | X-Ray Powder Diffraction (XRPD) | If polymorphism is a concern, XRPD is used to characterize crystalline form to ensure consistent physical properties across batches, which may affect solubility and stability. |
Technical Specifications of 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 148–152°C |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Conforms to reference spectrum |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE
Safety Information of 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE
Industrial 3-BROMOIMIDAZO[1,2-B]PYRIDAZINE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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