4-Chloro-2-iodo-benzoic acid Methyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 181765-85-5 |
| Product name | 4-Chloro-2-iodo-benzoic acid Methyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Chloro-2-iodo-benzoic acid Methyl ester
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Chloro-2-iodo-benzoic acid Methyl ester Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Chloro-2-iodo-benzoic acid Methyl ester
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key intermediate in the synthesis of anticancer agents (e.g., EGFR inhibitors) | Undergoes substitution with piperazine derivatives to construct the quinazoline core structure |
| Agrochemical R&D | Iodinated aryl building block for novel insecticidal molecules | Introduces specific side chains via Suzuki or Heck coupling to optimize biological activity |
| Organic Synthesis | Multifunctional halogenated aryl building block for selective functional group transformations | Iodine atom participates in metal-catalyzed cross-coupling reactions (e.g., Stille, Negishi); chlorine atom undergoes selective hydrolysis or aminolysis to introduce polar functional groups |
Manufacturing Quality Control of 4-Chloro-2-iodo-benzoic acid Methyl ester
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 254 nm, based on peak area comparison against reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities using gradient HPLC-UV; identification by retention time matching and/or spiked standards. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., methanol, dichloromethane) by gas chromatography with flame ionization detection using headspace sampling. |
| Water Content | Karl Fischer Titration | Determines trace water via coulometric or volumetric titration using iodine-based redox reaction in anhydrous pyridine/methanol medium. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, Hg, As) after acid digestion by inductively coupled plasma mass spectrometry with isotope dilution. |
| Chlorine Content | Oxygen Flask Combustion followed by Ion Chromatography | Organic chlorine is converted to chloride ion by combustion in oxygen, then quantified by ion chromatography with conductivity detection. |
| Iodine Content | Potentiometric Titration with Silver Nitrate | Total iodide is released by alkaline fusion or acid hydrolysis, then titrated with AgNO3 using silver indicator electrode for endpoint detection. |
| Acid Value | Acid-Base Titration | Measures free carboxylic acid groups by titration with standardized NaOH solution using phenolphthalein indicator. |
| Residue on Ignition | Gravimetric Analysis | Determines inorganic ash content by ignition at 600-700 C and weighing the residual residue after cooling in desiccator. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range at which solid transitions to liquid, indicating purity and identity via comparison to reference standard. |
| Specific Optical Rotation | Polarimetry | Measures rotation of plane-polarized light to detect chiral impurities or confirm enantiomeric integrity (if applicable). |
| Particle Size Distribution | Laser Diffraction | Analyzes dry powder particle size distribution using Mie scattering theory applied to laser diffraction pattern of dispersed sample. |
Technical Specifications of 4-Chloro-2-iodo-benzoic acid Methyl ester
| Test Item | Specification |
|---|---|
| Appearance | Orange solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 78–82°C |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Chloro-2-iodo-benzoic acid Methyl ester
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Chloro-2-iodo-benzoic acid Methyl ester
Safety Information of 4-Chloro-2-iodo-benzoic acid Methyl ester
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-Chloro-2-iodo-benzoic acid Methyl ester
Industrial 4-Chloro-2-iodo-benzoic acid Methyl ester Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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