4-Amino-2-fluoropyridine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 18614-51-2 |
| Product name | 4-Amino-2-fluoropyridine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Amino-2-fluoropyridine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Amino-2-fluoropyridine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Amino-2-fluoropyridine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of antitumor agents (e.g., BTK inhibitors) | Used to introduce aryl or heteroaryl groups via palladium-catalyzed cross-coupling reactions (e.g., Suzuki or Buchwald–Hartwig coupling) for constructing the core structure of targeted kinase inhibitors |
| Agrochemicals | Structural building block for novel herbicides and fungicides | Applied as a fluorinated heterocyclic synthon in nucleophilic substitution or cyclization reactions to modulate metabolic stability and target binding affinity of active molecules |
| Materials Science | Precursor for electron-transport layer materials in organic light-emitting diodes (OLEDs) | Derivatized via bromination, boronic esterification, etc., then incorporated into fluorinated nitrogen-containing heteroaromatic conjugated polymers through Suzuki coupling polymerization |
Manufacturing Quality Control of 4-Amino-2-fluoropyridine
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Characteristics | Visual Inspection + Physical Property Measurement | Observe sample color and state (typically white to off-white crystalline powder); determine melting point range (literature value approximately 120–125°C), conforming to pharmacopoeia or enterprise specifications. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a C18 column with water-acetonitrile or methanol-buffer salt (e.g., phosphate) mobile phase, UV detector (λ=254 nm), external standard method for quantification, ensuring main component content ≥98.0%. |
| Impurity Profile Analysis | HPLC-UV / HPLC-MS | Employ gradient elution to separate process impurities and degradation products (e.g., defluorinated derivatives, oxidized species, dimers), identify structures by comparison with reference standards or mass spectrometry, controlling individual impurities ≤0.1%, total impurities ≤0.5%. |
| Fluorine Content | Ion Chromatography (IC) or Oxygen Bomb Combustion-Ion Selective Electrode Method | After oxygen bomb combustion, the sample is absorbed into alkaline solution; F⁻ concentration is determined by ion chromatography or fluoride ion selective electrode, confirming fluorine content matches theoretical value (~13.5%). |
| Moisture Content | Karl Fischer Titration | Determine trace moisture using coulometric or volumetric Karl Fischer method, controlling moisture content ≤0.5% (may be relaxed to 1.0% depending on application), to prevent hydrolysis or crystal water effects on stability. |
| Solvent Residuals | Gas Chromatography (GC) | Use headspace injection or direct injection with DB-624 or HP-INNOWAX columns to detect residual solvents (e.g., methanol, acetonitrile, DMF, DMSO), complying with ICH Q3C guidelines. |
| Heavy Metals and Inorganic Impurities | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, measure levels of Pb, Cd, Hg, As, Cu and other heavy metals, controlled within ≤10 ppm (meeting pharmaceutical-grade standards). |
| pH Value (in Solution) | pH Meter Measurement | Prepare a 1% aqueous solution of the sample and measure pH at room temperature, typically controlled within 5.0–7.5, reflecting acid-base stability. |
| UV-Visible Absorption Spectroscopy | Ultraviolet-Visible Spectrophotometry (UV-Vis) | Scan in the 200–400 nm range to confirm characteristic absorption peaks (e.g., λmax ≈ 260–270 nm), used for preliminary identification and rapid purity screening. |
| Melting Point | Capillary Melting Point Apparatus | Determine the melting point range and compare with literature values (approximately 120–125°C) for preliminary identification and crystallinity assessment. |
| Polymorph Analysis (Optional) | X-Ray Powder Diffraction (XRPD) | Used to confirm crystalline form, preventing polymorphic variations that may affect solubility and stability; suitable for quality control of high-purity active pharmaceutical ingredients. |
Technical Specifications of 4-Amino-2-fluoropyridine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.5% (GC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 62–66°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.3% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Amino-2-fluoropyridine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Amino-2-fluoropyridine
Packaging of 4-Amino-2-fluoropyridine
Industrial 4-Amino-2-fluoropyridine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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