1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 188527-21-1 |
| Product name | 1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Used in the synthesis of active pharmaceutical ingredients (APIs), including antiviral agents and neuropeptide Y receptor antagonists | Employed as a chiral building block in multistep coupling reactions, such as Suzuki coupling, amidation, or deprotection–cyclization sequences |
| Organic Synthesis | Used as a chiral auxiliary and key building unit in asymmetric synthesis | Applied as a prochiral substrate or chiral inducer in palladium-catalyzed cross-coupling or enzymatic kinetic resolution |
| Fine Chemicals | Used to prepare novel catalyst ligands and functionalized heterocyclic compounds | Subjected to N-decarbobenzyloxylation followed by condensation with aldehydes/ketones, or ester hydrolysis/reduction to yield corresponding amine or alcohol derivatives |
Manufacturing Quality Control of 1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase chromatography with UV detection at 210 nm based on peak area comparison against reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities by retention time and peak area relative to main peak using gradient elution. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., methanol, ethyl acetate) via gas chromatography with flame ionization detection using headspace sampling. |
| Water Content | Karl Fischer Titration | Determines trace water by coulometric or volumetric titration where iodine reacts stoichiometrically with water in a pyridine-methanol buffer. |
| Heavy Metals | ICP-OES | Quantifies metals (e.g., Pb, Cd, Ni, Fe) after acid digestion by measuring element-specific atomic emission intensities in plasma. |
| Chloride Impurity | Ion Chromatography | Separates and quantifies chloride ions using anion-exchange column with suppressed conductivity detection. |
| Sulfated Ash | Gravimetric Analysis | Measures inorganic residue after controlled combustion at 700-800 C followed by precise weighing of residual ash. |
| Optical Rotation | [alpha]D Measurement | Determines specific rotation using sodium D-line light source to confirm chiral integrity and enantiomeric purity. |
| Melting Point | Capillary Melting Point Apparatus | Identifies melting range by observing phase transition under controlled heating; confirms identity and crystallinity. |
| Residual Catalyst (Pd) | ICP-MS | Detects palladium traces at sub-ppq levels after microwave digestion using inductively coupled plasma mass spectrometry. |
| pH of Aqueous Solution | Potentiometric pH Measurement | Measures hydrogen ion activity in 1% w/v aqueous suspension using calibrated glass electrode and reference electrode. |
| Particle Size Distribution | Laser Diffraction | Analyzes dry powder size distribution by measuring angular variation in laser light scattering intensity. |
Technical Specifications of 1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 142–146 °C |
| Identification (NMR) | Consistent with structure |
| Optical Rotation | [α]D²⁰ = -15.0 to -19.0° (c=1, in methanol) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID
Safety Information of 1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID
Industrial 1-N-CBZ-PYRROLIDINE-3-CARBOXYLIC ACID Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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