1-Boc-4-methoxypiperidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 188622-27-7 |
| Product name | 1-Boc-4-methoxypiperidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 1-Boc-4-methoxypiperidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 1-Boc-4-methoxypiperidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 1-Boc-4-methoxypiperidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Key intermediate for synthesizing selective 5-HT2C receptor agonists (e.g., lorcaserin) | Provides the piperidine ring structure in coupling reactions; target molecule core scaffold is constructed via deprotection, amidation, and related steps |
| Pharmaceutical R&D | Candidate drug synthesis for Akt inhibitors containing a 1-piperidinecarboxylate motif | Chiral building block used in Suzuki coupling or reductive amination to introduce a 4-methoxy-substituted piperidine fragment |
| Fine Chemicals | Multifunctional protecting group reagent for selective protection of the piperidine nitrogen atom and subsequent functional group transformations | Forms imines with aldehydes/ketones under basic conditions or undergoes N-alkylation with halides; the t-Boc group is efficiently removed using TFA |
Manufacturing Quality Control of 1-Boc-4-methoxypiperidine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 210-220 nm. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC with UV detection; identification based on retention time relative to reference standards. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify common organic solvents (e.g., methanol, THF, toluene) based on calibrated response factors. |
| Water Content | Karl Fischer Titration | Electrochemical titration using iodine generated in situ to determine water content via stoichiometric reaction with pyridine and methanol in KF reagent. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, As) after acid digestion, using mass spectrometry for high sensitivity and selectivity. |
| Chloride Content | Ion Chromatography | Separation and conductivity detection of chloride ions after sample dissolution and filtration; quantified against sodium chloride calibration standards. |
| Residual Palladium | ICP-OES | Quantification of palladium residues after microwave-assisted acid digestion, using optical emission spectroscopy at characteristic wavelengths. |
| Optical Rotation | [alpha]D Measurement | Determination of specific rotation using a digital polarimeter at 20 C and sodium D-line (589 nm) to confirm chiral integrity and enantiomeric purity. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed visually or automatically as the temperature range over which solid-to-liquid phase change occurs under controlled heating rate. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity against established reference standards under controlled lighting and viewing conditions. |
| Loss on Drying | Gravimetric Analysis | Mass loss measured after drying under specified vacuum/temperature conditions, indicating volatile content including residual solvents and moisture. |
| pH of Aqueous Suspension | pH Meter | Measurement of pH in a defined suspension (e.g., 1% w/v in water) using calibrated pH electrode to assess acidic/basic degradation products. |
Technical Specifications of 1-Boc-4-methoxypiperidine
| Test Item | Specification |
|---|---|
| Appearance | Colourless liquid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Odor | Characteristic odour |
| Solubility | Soluble in common organic solvents (e.g., dichloromethane, ethanol, ethyl acetate) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 1-Boc-4-methoxypiperidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 1-Boc-4-methoxypiperidine
Packaging of 1-Boc-4-methoxypiperidine
Industrial 1-Boc-4-methoxypiperidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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