China Factory Direct
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| CAS number | 189680-06-6 |
| Product name | 2-BROMO-5-HYDROXYBENZONITRILE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Used as precursors in the synthesis of anticancer, anti-inflammatory, or neuroactive drugs | Employed as aryl bromides in Suzuki coupling, nucleophilic substitution, or cyano group transformations to construct complex molecular frameworks |
| Agrochemical Intermediates | Used to synthesize herbicidal or insecticidal active ingredients containing benzonitrile motifs | Subjected to halogen exchange, hydroxyl protection/deprotection, and cyano group derivatization to introduce target functional groups |
| Organic Synthesis Reagents | Serve as versatile building blocks for the synthesis of heterocyclic or functionalized aromatic compounds | Utilized for metal-catalyzed cross-coupling via the bromine atom, or for esterification, etherification, and other derivatization reactions via the hydroxyl group |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase HPLC with UV detection at 220-254 nm based on peak area comparison to reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities (e.g., isomers, bromination by-products) using gradient HPLC-UV against qualified reference standards. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., acetonitrile, toluene) by gas chromatography with flame ionization detection using internal standard calibration. |
| Water Content | Karl Fischer Titration | Determines trace water via coulometric or volumetric titration using iodine generated electrochemically in a methanol-based reagent. |
| Heavy Metals | ICP-MS | Quantifies toxic elements (Pb, Cd, Hg, As) after acid digestion by inductively coupled plasma mass spectrometry with isotope dilution or external calibration. |
| Residue on Ignition | Gravimetric Analysis | Measures inorganic ash content by ignition at 700-800 C followed by precise weighing of residual non-volatile matter. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using calibrated capillary tube method per USP <741>. |
| Chloride Impurity | Ion Chromatography | Quantifies chloride ions after sample dissolution and filtration using suppressed conductivity detection with sodium carbonate eluent. |
| Sulfated Ash | Gravimetric Analysis | Measures inorganic residue after sulfuric acid treatment and high-temperature incineration, per USP <281>. |
| Particle Size Distribution | Laser Diffraction | Analyzes dry or wet dispersed sample using Mie theory to calculate size distribution from scattered laser light intensity. |
| Bulk Density | Tap Density Tester | Determines mass per unit volume of powder after controlled tapping per USP <616> using standardized apparatus. |
| pH of Aqueous Suspension | Potentiometric pH Measurement | Measures hydrogen ion activity in a saturated aqueous suspension using calibrated glass electrode and pH meter. |
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.0% (GC-MS) |
| Melting Point | 124–128°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.