Ritalinic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 19395-41-6 |
| Product name | Ritalinic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Ritalinic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Ritalinic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Ritalinic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Synthesis of pharmaceutical intermediates for central nervous system (CNS)-targeted drug development | Construction of the phenylpiperidine scaffold via organic synthesis, followed by acetic acid side-chain modification |
| Chemical Research | Research compound for structure–activity relationship (SAR) studies of novel analgesic or antipsychotic agents | Used in laboratory-scale synthesis and structural optimization experiments |
| Biotechnology | Synthetic precursor for bioactive molecules in receptor-targeting studies | Introduced as a key intermediate in multistep syntheses to install specific functional groups |
Manufacturing Quality Control of Ritalinic acid
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Chemical Purity and Main Component Content | High-Performance Liquid Chromatography (HPLC) | Using a reversed-phase C18 chromatographic column with gradient elution of water-organic solvent (such as methanol or acetonitrile), and detection by UV detector (usually 210–254 nm). The main component content and impurity levels are determined by comparing retention time with standard substances and quantifying peak area, in accordance with pharmacopoeia methods (e.g., USP/EP). |
| Impurity Profile Analysis | High-Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS/MS) | Based on HPLC separation, combined with mass spectrometry for identification of known or unknown impurities. Suitable for detecting impurities introduced during synthesis, such as starting materials, intermediates, and degradation products (e.g., decarboxylation products, oxides), enabling qualitative and quantitative analysis of trace impurities. |
| Moisture Content | Karl Fischer Titration | Utilizes an iodine-sulfur dioxide-pyridine-methanol system reacting specifically with water, and determines trace moisture content using potentiometric or coulometric methods. Applicable for controlling the impact of moisture on stability in bulk drug substances, in compliance with Chinese Pharmacopoeia General Rule 0832. |
| Melting Point | Melting Point Determination Method | Measures the melting point range using capillary or automatic melting point apparatus, compared with literature values (typically around 120–130°C), used to preliminarily assess crystal form consistency and purity. |
| Optical Rotation | Polarimeter Method | If α-phenylpiperidin-2-acetic acid contains a chiral center (e.g., a chiral compound), its specific optical rotation must be measured. Using a sodium lamp (589 nm) in a specified solvent (e.g., ethanol or water), to evaluate optical purity and determine whether racemization has occurred. |
| Residual Solvents | Gas Chromatography (GC) | Using headspace or direct injection GC-FID/ECD, detects residual organic solvents (e.g., methanol, ethanol, dichloromethane, acetonitrile) from synthesis processes, ensuring compliance with toxicity limits according to ICH Q3C guidelines. |
| Heavy Metals and Inorganic Impurities | Atomic Absorption Spectrometry (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Determines heavy metal content (e.g., lead, cadmium, mercury, arsenic) after sample digestion, in compliance with ICH Q3D guidelines, to ensure drug safety. |
| pH Value (in Aqueous Solution) | pH Meter Method | Prepares a solution of defined concentration (e.g., 10 mg/mL) and measures pH using a calibrated pH meter, assessing acidity/basicity to determine whether it meets formulation process requirements (e.g., for salt form preparation). |
| Chloride/Sulfate Ion | Ion Chromatography (IC) or Precipitation Titration | Detects inorganic anion impurities (e.g., from hydrochloric acid or sulfuric acid used in synthesis), using ion chromatography for separation and detection, or silver nitrate titration to measure chloride content. |
| Polymorphic Analysis | X-ray Powder Diffraction (XRPD) | If polymorphism exists, confirms polymorphic consistency by comparing characteristic diffraction peaks in XRPD patterns, ensuring formulation stability and dissolution performance. |
Technical Specifications of Ritalinic acid
| Test Item | Specification |
|---|---|
| Appearance | White to light yellow crystalline powder |
| Purity | >=98.0% (HPLC) |
| Melting Point | 124-128°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Ritalinic acid
| CAS/Product ID | *Required fields | |
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NMR Spectra of Ritalinic acid
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Industrial Ritalinic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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