Cbz-Valine ganciclovir Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 194154-40-0 |
| Product name | Cbz-Valine ganciclovir |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Cbz-Valine ganciclovir
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Cbz-Valine ganciclovir Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Cbz-Valine ganciclovir
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D and Manufacturing | Intermediate in the synthesis of antiviral drugs—particularly for cytomegalovirus (CMV) infection—as a prodrug precursor to valganciclovir | In the chemical synthesis of valganciclovir, Cbz-valganciclovir undergoes palladium-on-carbon-catalyzed hydrogenolysis to remove the Cbz (benzyloxycarbonyl) protecting group, yielding valganciclovir with a free amino group; this step is typically conducted at room temperature under ambient or reduced hydrogen pressure in alcoholic solvents (e.g., methanol or ethanol) |
Manufacturing Quality Control of Cbz-Valine ganciclovir
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reverse-phase HPLC with UV detection at 254 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV/DAD | Separation and identification of impurities using gradient HPLC with diode-array detection; qualification based on retention time and spectral match. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection, quantifying volatile organic solvents per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration measuring water via iodine generation and stoichiometric reaction with sample moisture. |
| Heavy Metals | ICP-MS | Quantitative determination of elemental impurities (e.g., Pb, Cd, As, Hg) using inductively coupled plasma mass spectrometry per ICH Q3D. |
| Chloride Impurity | Ion Chromatography (IC) | Separation and quantification of chloride ions using suppressed conductivity detection after anion exchange. |
| Residual Palladium | ICP-MS | Specific quantification of palladium residue from catalytic hydrogenation steps, per ICH Q3D Class 1 element limits. |
| Optical Rotation | [α]D Measurement | Determination of specific optical rotation using a polarimeter at 20 °C and sodium D-line (589 nm) to confirm chiral integrity. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersed sample to determine volume-based particle size distribution (D10, D50, D90). |
| Microbial Limits | Membrane Filtration + TSA/SDA | Enumeration of aerobic microorganisms and detection of specified pathogens using pharmacopeial-compliant culture methods. |
| Residual Host Cell Proteins | ELISA | Immunological quantification using antibody-based capture and enzymatic colorimetric detection. |
| pH (1% w/v aqueous suspension) | Potentiometric pH Measurement | Direct measurement using calibrated pH electrode in a standardized aqueous suspension per USP <791>. |
Technical Specifications of Cbz-Valine ganciclovir
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 148°C - 152°C |
| Optical Rotation | -15.0° to -19.0° (c=1, in methanol) |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Cbz-Valine ganciclovir
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Cbz-Valine ganciclovir
Packaging of Cbz-Valine ganciclovir
Industrial Cbz-Valine ganciclovir Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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