6-Hydroxypicolinic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 19621-92-2 |
| Product name | 6-Hydroxypicolinic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 6-Hydroxypicolinic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 6-Hydroxypicolinic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 6-Hydroxypicolinic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of the antitumor drug everolimus | Introduces the pyridyl side chain structure via multi-step reactions—including amidation, alkylation, and macrocyclization—within the total synthesis route of everolimus |
| Agrochemicals | Intermediate for the development of novel herbicides and plant growth regulators | Used to construct nitrogen-containing heterocyclic active molecular scaffolds; participates in coupling or condensation reactions to optimize target activity and selectivity |
| Materials Science | Precursor ligand for metal–organic frameworks (MOFs), employed in the preparation of functionalized porous materials | Coordinates with transition metals (e.g., Fe³⁺, Cu²⁺) through dual functional groups—carboxyl and hydroxyl—to form stable coordination polymer structures |
Manufacturing Quality Control of 6-Hydroxypicolinic acid
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the sample's color, physical state, and visible impurities under natural light or standard illumination. Typically appears as a white to off-white crystalline powder. |
| Identification | Fourier Transform Infrared Spectroscopy (FT-IR) | Compare the sample spectrum with the reference standard spectrum by analyzing characteristic functional group absorption peaks (e.g., O-H, C=O, C=N) to confirm molecular structure. |
| Proton Nuclear Magnetic Resonance (¹H-NMR) | Dissolve the sample in a suitable solvent such as DMSO-d₆, then analyze chemical shifts, coupling constants, and integration ratios to confirm molecular structure. | |
| High-Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS) | Confirm structural identity by matching retention time and mass-to-charge ratio (m/z) with those of the reference standard. | |
| Purity/Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with water-methanol or buffer solution as mobile phase; detect at UV wavelength (e.g., 254 nm or 280 nm); calculate main component content using external standard method or area normalization. |
| Moisture Content | Karl Fischer Titration | Quantitatively determine moisture content based on the reaction between iodine and sulfur dioxide in a pyridine/methanol system; suitable for trace water analysis. |
| Drying Loss | Thermogravimetric Analysis (TGA) or Oven Drying Method | Dry the sample at a specified temperature (e.g., 105°C) until constant weight is achieved; calculate volatile matter content based on weight loss. |
| Residue on Ignition (Sulfated Ash) | Gravimetric Method | After high-temperature incineration, weigh the residual inorganic matter to determine the percentage of inorganic impurities. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | After sample digestion, measure levels of heavy metals such as lead, cadmium, mercury, and arsenic; ensure compliance with pharmacopoeial or international standards. |
| Related Substances (Impurities) | HPLC (Gradient Elution) | Optimize chromatographic conditions to separate the main peak from impurity peaks; detect degradation products or synthetic intermediates; use relative retention times and peak areas for qualitative and quantitative analysis. |
| pH Value | pH Meter Measurement | Dissolve the sample in water at a defined concentration (e.g., 1% w/v), then measure pH using a calibrated pH meter. |
| Melting Point | Melting Point Apparatus Measurement | Determine the initial and final melting temperatures using an automatic or capillary melting point apparatus to assess purity and consistency. |
Technical Specifications of 6-Hydroxypicolinic acid
| Test Item | Specification |
|---|---|
| Appearance | Light yellow to brown powder or crystals |
| Purity | >=98.0% (HPLC) |
| Melting Point | 198–202 °C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 6-Hydroxypicolinic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 6-Hydroxypicolinic acid
Packaging of 6-Hydroxypicolinic acid
Industrial 6-Hydroxypicolinic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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