N-Acetyl-D-leucine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 19764-30-8 |
| Product name | N-Acetyl-D-leucine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent GradeFood Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-Acetyl-D-leucine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Acetyl-D-leucine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Acetyl-D-leucine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Used as a synthetic drug intermediate for the preparation of antibiotics and anti-inflammatory agents | Conjugated with amino acid derivatives via acylation, followed by deprotection and purification to yield the target compound |
| Biopharmaceuticals | Employed as a protected amino acid building block in peptide synthesis | Serves as a starting material or intermediate in solid-phase or solution-phase peptide synthesis, providing defined side-chain functionality |
| Food Additives | Used as a raw material for functional food ingredients (e.g., sports nutrition products) | Produced via enzymatic or chemical synthesis, followed by rigorous purification for use in nutritional supplements |
| Chemical Research | Applied as a chiral synthetic reagent for developing novel catalysts or molecular probes | Chiral centers are constructed using asymmetric synthesis techniques for organic synthesis research |
Manufacturing Quality Control of N-Acetyl-D-leucine
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Characteristics | Visual Inspection and Physical Property Testing | Observe sample color, state (white crystalline or powder), and solubility (usually soluble in water and ethanol, slightly soluble in ether), in accordance with pharmacopoeia or enterprise standards. |
| Identification | Infrared Spectroscopy (IR) | Confirm the structure by comparing characteristic IR absorption peaks (e.g., amide I band 1650–1680 cm⁻¹, amide II band 1540–1570 cm⁻¹, carboxylic acid O-H stretch) with reference spectra. |
| High-Performance Liquid Chromatography (HPLC) | Using a chiral column or standard comparison, confirm the identity of the target compound by retention time, excluding interference from D/L isomers or impurities. | |
| Assay | High-Performance Liquid Chromatography (HPLC) | Use a UV detector (210–220 nm) or Evaporative Light Scattering Detector (ELSD), quantify using external or internal standard method with reference standards, calculate the percentage of the main component (typically ≥98.0%). |
| Titration (Acid-Base Titration) | Utilize the acidity of the carboxyl group, titrate with standard sodium hydroxide solution. Suitable for high-purity samples but susceptible to interference from impurities; often used for quick screening. | |
| Enantiomeric Purity (D/L Form) | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Separate D- and L-enantiomers using a chiral stationary phase (e.g., cellulose derivatives, cyclodextrin columns), measure the D-form content to ensure enantiomeric purity (typically ≥99% ee). |
| Water Content | Karl Fischer Titration | Quantitatively determine trace moisture content via electrochemical reaction, in compliance with pharmacopoeia requirements (e.g., ≤0.5%), to ensure stability and storage conditions. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Determine lead, cadmium, mercury, arsenic, etc., after sample digestion, in compliance with ICH Q3D or pharmacopoeia limits (e.g., ≤10 ppm). |
| Residual Solvents | Gas Chromatography (GC) | Detect residual organic solvents such as ethanol, acetone, ethyl acetate using headspace or direct injection, in compliance with ICH Q3C standards. |
| Sulfated Ash (Residue on Ignition) | Residue on Ignition Test | Ignite sample at high temperature (500–600°C), weigh the residue to assess inorganic impurities (typically ≤0.1%). |
| Solution Clarity and Color | Visible Spectrophotometry or Visual Method | Prepare solution at specified concentration, compare with standard color solutions to assess clarity and color (e.g., colorless or pale yellow), meeting appearance requirements. |
| Microbial Limits (if applicable) | Plate Count Method / Membrane Filtration Method | For non-sterile APIs, test total aerobic microbial count, molds and yeasts, Escherichia coli, etc., in compliance with pharmacopoeia microbial limit standards (e.g., ≤10³ CFU/g). |
Technical Specifications of N-Acetyl-D-leucine
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 123°C to 127°C |
| Optical Rotation | +20.0° to +24.0° (c=1, in 1M HCl) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-Acetyl-D-leucine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Acetyl-D-leucine
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Industrial N-Acetyl-D-leucine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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