FMOC-L-PROPARGYLGLYCINE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 198561-07-8 |
| Product name | FMOC-L-PROPARGYLGLYCINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for FMOC-L-PROPARGYLGLYCINE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk FMOC-L-PROPARGYLGLYCINE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of FMOC-L-PROPARGYLGLYCINE
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as a non-natural amino acid in peptide synthesis to introduce alkyne functionality for click chemistry reactions (e.g., CuAAC) | Employed as an Fmoc-protected building block in solid-phase peptide synthesis (SPPS) for chain elongation; subsequent deprotection and click chemistry enable bioorthogonal labeling or conjugation |
| Biochemical Research | Used for site-specific modification in protein engineering and chemical biology | Undergoes copper-catalyzed azide–alkyne cycloaddition (Click Chemistry) with azides to achieve fluorescent labeling, biotinylation, or conjugation with other molecules |
| Medicinal Chemistry | Used as an intermediate in developing novel alkyne-containing peptide therapeutics or probe molecules | Introduced as a propargylglycine residue during lead compound optimization to modulate pharmacokinetic properties or enable targeted delivery |
Manufacturing Quality Control of FMOC-L-PROPARGYLGLYCINE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 270 nm based on peak area comparison against reference standard. |
| Chiral Purity | Chiral HPLC | Separates enantiomers on a chiral stationary phase and quantifies L-isomer excess relative to D-isomer using UV detection. |
| Water Content | Karl Fischer Titration | Determines water by coulometric or volumetric titration with iodine generated in situ via reaction with water in methanol-based solvent. |
| Residual Solvents | GC-FID | Identifies and quantifies volatile organic solvents (e.g., DMF, DCM, MeOH) using gas chromatography with flame ionization detection. |
| Heavy Metals | ICP-MS | Measures trace metal impurities (e.g., Pb, Cd, Ni, Fe) after acid digestion by detecting elemental mass-to-charge ratios with high sensitivity. |
| Residual Palladium | ICP-OES | Quantifies palladium from coupling catalyst residues after microwave-assisted acid digestion using atomic emission at characteristic wavelengths. |
| Acid Value | Acid-Base Titration | Determines free carboxylic acid content by titration with standardized NaOH solution using phenolphthalein indicator. |
| Optical Rotation | [alpha]D Measurement | Measures specific rotation of sample solution at 589 nm using sodium D-line light to confirm chiral integrity and concentration. |
| Particle Size Distribution | Laser Diffraction | Analyzes dry or wet dispersed powder to determine size distribution based on angular scattering intensity of laser beam. |
| Microbial Limits | Membrane Filtration | Detects aerobic microorganisms by filtration, membrane transfer to agar media, and colony enumeration after incubation. |
| Related Substances | HPLC-UV | Identifies and quantifies structurally related impurities (e.g., deprotected FMOC, hydrolyzed glycine derivatives) using gradient HPLC-UV. |
| Loss on Drying | Gravimetric Analysis | Determines volatile matter by measuring weight loss after heating sample at 105 C under vacuum for specified time. |
Technical Specifications of FMOC-L-PROPARGYLGLYCINE
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | +7.0 to +9.0 (c=1, DMF) |
| Identification (NMR) | Consistent with structure |
| Melting Point | 148 to 152 °C |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of FMOC-L-PROPARGYLGLYCINE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of FMOC-L-PROPARGYLGLYCINE
Packaging of FMOC-L-PROPARGYLGLYCINE
Industrial FMOC-L-PROPARGYLGLYCINE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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