BOC-N-methyl-D-alanine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 19914-38-6 |
| Product name | BOC-N-methyl-D-alanine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for BOC-N-methyl-D-alanine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk BOC-N-methyl-D-alanine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of BOC-N-methyl-D-alanine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Chiral drug synthesis intermediate for constructing N-methyl-D-alanine-containing peptide therapeutics (e.g., protease inhibitors, antimicrobial peptides) | Used as a protected D-configured amino acid monomer in solid-phase peptide synthesis (SPPS), coupled via Fmoc/t-Bu or Boc/Bn strategies; subsequent deprotection of the Boc group with trifluoroacetic acid (TFA) |
| Biochemical Research | D-Amino acid-specific probe and enzymatic substrate for investigating stereoselective mechanisms of D-amino acid oxidase (DAO), peptidases, and related enzymes | Employed as a specific substrate in in vitro enzymatic reaction systems; D-configuration-dependent transformation products detected by HPLC or MS |
| Asymmetric Catalysis | Building block for chiral ligands or catalysts, enabling synthesis of chiral phosphine ligands or metal complexes incorporating an N-methyl-D-alanine scaffold | After derivatization via amide or ester bond formation, coordinated with transition metals (e.g., Pd, Rh) for asymmetric C–C coupling or hydrogenation reactions |
Manufacturing Quality Control of BOC-N-methyl-D-alanine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at 210 nm, comparing peak area to a certified reference standard. |
| Chiral Purity | Chiral HPLC | Enantiomeric excess assessment using a chiral stationary phase and UV detection, resolving D- and L-enantiomers. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration based on the stoichiometric reaction of iodine with water in pyridine/methanol medium. |
| Residual Solvents | GC-FID | Identification and quantification of volatile organic solvents (e.g., DMF, methanol) using gas chromatography with flame ionization detection. |
| Heavy Metals | ICP-MS | Multi-element trace metal quantification (e.g., Pb, Cd, Hg, As) via inductively coupled plasma mass spectrometry after acid digestion. |
| Chloride Impurity | Ion Chromatography | Quantitative analysis of chloride anion using suppressed conductivity detection after separation on an anion-exchange column. |
| Sulfate Impurity | Ion Chromatography | Quantitative analysis of sulfate anion using suppressed conductivity detection after separation on an anion-exchange column. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities (e.g., BOC-D-alanine, N-methyl-D-alanine) using gradient HPLC-UV. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity against defined standards under controlled lighting conditions. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, using calibrated capillary apparatus per USP <741>. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light in solution, indicating chiral integrity and concentration. |
| Residue on Ignition | Gravimetric Analysis | Quantification of non-volatile inorganic residue after high-temperature ashing (700-800 C) and weighing. |
Technical Specifications of BOC-N-methyl-D-alanine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Melting Point | 142-146°C |
| Optical Rotation | +29.0 to +31.0° (c=1, in methanol) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of BOC-N-methyl-D-alanine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of BOC-N-methyl-D-alanine
Packaging of BOC-N-methyl-D-alanine
Industrial BOC-N-methyl-D-alanine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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