N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 199593-09-4 |
| Product name | N-Acetyl-5'-O-(4,4-dimethoxytrityl)-2'-O-methylcytidine-3'-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 199593-09-4
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 199593-09-4 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 199593-09-4
| Industry | Application | Process |
|---|---|---|
| Biopharmaceuticals | Synthesis of nucleoside analogs for antiviral and anticancer drugs | Organic synthesis to install N-acetyl, 5′-O-(4,4-dimethoxytrityl), 2′-O-methyl, and 3′-(2-cyanoethyl-N,N-diisopropyl)phosphoramidite groups onto a cytidine scaffold |
| Chemical Reagents | Synthetic intermediate for constructing nucleotides with specific structures | Multi-step organic synthesis, including introduction and removal of protecting groups, phosphorylation, and related reactions |
| Nucleic Acid Chemistry | Modified monomer for solid-phase oligonucleotide synthesis, particularly in RNA synthesis | Used as a protected nucleotide monomer in solid-phase synthesis to construct functionalized oligonucleotide strands |
Manufacturing Quality Control of 199593-09-4
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 260 nm. |
| Related Substances | HPLC-UV | Separation and detection of structurally related impurities using gradient HPLC with UV detection; identification and quantification relative to main peak. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents (e.g., acetonitrile, dichloromethane, THF) based on calibrated response factors. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content via stoichiometric reaction with iodine and sulfur dioxide. |
| Optical Rotation | [alpha]D Measurement | Measurement of specific optical rotation using a polarimeter at 20 degrees C and sodium D-line (589 nm) to confirm chiral integrity and batch consistency. |
| Residual Metals (e.g., Fe, Cu, Ni) | ICP-MS | Quantitative determination of trace metal contaminants after acid digestion using inductively coupled plasma mass spectrometry with isotope dilution or external calibration. |
| Acid Value | Acid-Base Titration | Titration with standardized potassium hydroxide solution to determine free acidic functional groups (e.g., residual phosphonic or carboxylic acids) using phenolphthalein endpoint. |
| Phosphitylation Efficiency | 31P NMR Spectroscopy | Quantitative assessment of phosphoramidite group integrity and side products (e.g., hydrolyzed phosphate, H-phosphonate) via integration of characteristic 31P chemical shifts. |
| Particle Size Distribution | Laser Diffraction | Measurement of dry powder particle size distribution using laser scattering principles and Mie theory for aerodynamic and handling performance evaluation. |
| Microbial Contamination | Membrane Filtration | Enumeration of aerobic microorganisms by filtration, membrane transfer to culture media, and colony counting after incubation per USP <61>. |
| Residual Cyanide | Ion Chromatography | Separation and quantification of free cyanide ions (CN-) after alkaline extraction using anion-exchange column and suppressed conductivity detection. |
| Stereochemical Purity (2'-O-Methyl epimer) | Chiral HPLC | Separation of diastereomeric impurities at the 2'-position using chiral stationary phase and UV detection to assess epimeric purity. |
Technical Specifications of 199593-09-4
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (by LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Optical Rotation | -15° to -25° (c=1, CHCl3) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 199593-09-4
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 199593-09-4
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Industrial 199593-09-4 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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