Calcium dobesilate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 20123-80-2 |
| Product name | Calcium dobesilate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Calcium dobesilate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Calcium dobesilate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Calcium dobesilate
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Drugs for improving microcirculatory disorders | Oral administration |
| Healthcare | Treatment of diabetic retinopathy | Used in conjunction with other therapeutic modalities |
| Healthcare | Treatment of varicose vein syndrome | Intravenous injection or oral administration |
| Healthcare | Treatment of chronic venous insufficiency | Oral administration |
Manufacturing Quality Control of Calcium dobesilate
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identification Test | Infrared Spectroscopy (IR) | Determine the infrared absorption spectrum of the sample and compare it with the reference spectrum to confirm molecular structural characteristics. |
| Calcium Ion Reaction | Use reagents such as ammonium oxalate to react with calcium ions, forming a white precipitate (calcium oxalate) for qualitative identification. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column, elute with a specific mobile phase (e.g., phosphate buffer-methanol), and quantify the main component using a UV detector (typically at 230–260 nm). |
| Non-aqueous Titration | Perform titration in a non-aqueous solvent (e.g., glacial acetic acid) using perchloric acid as titrant, determining the content of basic functional groups via potentiometric or indicator methods, thereby calculating the active pharmaceutical ingredient content indirectly. | |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Employ gradient or isocratic elution to separate and detect related impurities (e.g., p-hydroxybenzenesulfonic acid, intermediates) formed during synthesis. Quantification is typically performed using area normalization or reference standard method. |
| Drying Loss | Thermogravimetric Analysis / Constant Temperature Drying under Atmospheric Pressure | Dry the sample at a specified temperature (e.g., 105°C) until constant weight, then determine the percentage by mass of lost water and other volatile components. |
| Residue on Ignition | High-Temperature Incineration Method | Char the sample first, then ignite at 700–800°C to determine the weight of residual inorganic matter (mainly calcium sulfate, etc.). |
| Heavy Metals | Thioacetamide Method (Colorimetry) | React the sample with thioacetamide under weakly acidic conditions to form a colored sulfide precipitate; compare with a lead standard solution for colorimetric control of total heavy metal content. |
| pH Value | pH Meter Measurement | Prepare a solution of specified concentration (e.g., 1%) and directly measure its acidity or alkalinity using a calibrated pH meter. |
| Solution Clarity and Color | Visual Turbidity/Color Comparison Method | Compare the test solution visually with turbidity standards or color comparison solutions to assess clarity and any abnormal discoloration. |
| Water Content | Karl Fischer Titration | Quantitatively determine trace amounts of water in the sample using the iodine-sulfur dioxide reaction; suitable for thermally unstable or hydrate-containing drugs. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace injection or direct injection, separate analytes via capillary column, and detect residual organic solvents (e.g., methanol, ethanol, acetone) from manufacturing processes using a flame ionization detector (FID). |
Technical Specifications of Calcium dobesilate
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
| Melting Point | 134-138°C |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Calcium dobesilate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of Calcium dobesilate
Packaging of Calcium dobesilate
Industrial Calcium dobesilate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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