H-D-THR(TBU)-OH Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 201274-81-9 |
| Product name | H-D-THR(TBU)-OH |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for H-D-THR(TBU)-OH
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk H-D-THR(TBU)-OH Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of H-D-THR(TBU)-OH
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key chiral intermediate for the synthesis of the antibiotic tigecycline | Used as a chiral precursor to construct the glycylcyclopropane moiety of tigecycline, introduced into the target structure via coupling reaction |
| Chemical Synthesis | Chiral building block for preparing other bioactive molecules | Applied as a stereochemically defined building block in multistep organic synthesis, participating in amide bond formation or protecting group manipulations |
| Biopharmaceutical R&D | Research reagent for developing novel tetracycline-class antibacterial agents | Used at laboratory scale for structural modification and structure–activity relationship (SAR) studies to optimize metabolic stability and biological activity |
Manufacturing Quality Control of H-D-THR(TBU)-OH
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC with Chiral Column | Enantioselective separation and quantification using a chiral stationary phase and UV detection at ~210 nm, calibrated against certified reference standard. |
| Specific Optical Rotation | [α]D | Measurement of rotation of plane-polarized light at 589 nm using a digital polarimeter; confirms enantiomeric identity and purity based on literature value (e.g., +24.5° to +26.5°, c = 1 in 1 M HCl). |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration quantifying water via iodine generation and stoichiometric reaction with water in anhydrous methanol-based reagent. |
| Residual Solvents | GC-FID with Headspace Sampling | Separation and quantification of volatile organic solvents (e.g., methanol, acetone, ethyl acetate) using capillary column and flame ionization detection. |
| Heavy Metals (Pb, Cd, Hg, As) | ICP-MS | Multi-element quantification at trace levels (ppq–ppt) after acid digestion, leveraging high mass resolution and sensitivity for toxic elemental impurities. |
| Chloride Impurity | Ion Chromatography (IC) with Conductivity Detection | Anion separation on a high-capacity suppressor column followed by quantitative conductivity detection of Cl⁻. |
| Related Substances (Impurity Profile) | HPLC with UV Detection | Reverse-phase separation on C18 column with gradient elution and UV detection at 210 nm; identification/quantification against qualified impurity standards. |
| Residue on Ignition (Sulfated Ash) | Gravimetric Analysis | High-temperature incineration (~750 °C) followed by sulfuric acid treatment and weighing of inorganic residue as sulfate ash. |
| pH (1% w/v aqueous solution) | Potentiometric pH Measurement | Direct measurement using calibrated glass electrode in aqueous suspension, reflecting acid-base behavior and potential salt formation. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity vs. angle to determine volumetric particle size distribution in dispersed solid sample. |
| Microbial Limits | Membrane Filtration & Plate Count | Enumeration of aerobic mesophilic microorganisms and detection of specified pathogens (e.g., E. coli, S. aureus) per Ph. Eur./USP <61> and <62>. |
Technical Specifications of H-D-THR(TBU)-OH
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% |
| Water Content (KF) | <=0.5% |
| Melting Point | 142-146°C |
| Optical Rotation | +43.0 to +47.0° (c=1, in 1M HCl) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of H-D-THR(TBU)-OH
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of H-D-THR(TBU)-OH
Packaging of H-D-THR(TBU)-OH
Industrial H-D-THR(TBU)-OH Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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