N-BOC-cis-4-fluoro-L-proline Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 203866-13-1 |
| Product name | N-BOC-cis-4-fluoro-L-proline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-BOC-cis-4-fluoro-L-proline
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-BOC-cis-4-fluoro-L-proline Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-BOC-cis-4-fluoro-L-proline
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Used as a key intermediate in the synthesis of fluorinated drug molecules, such as protease inhibitors and antiviral agents (e.g., HIV therapeutics) | Applied in chiral synthesis, solid-phase peptide synthesis, and introduction/removal of Boc protecting groups |
| Biochemistry | Used to prepare fluorinated amino acid-containing peptide analogues for studying protein structure and function | Applied in peptide chain assembly and incorporation of fluorinated amino acids |
| Academic Research | Used as a chiral building block for developing organic synthetic methodologies and investigating stereoelectronic effects of fluorine atoms in molecules | Applied in asymmetric synthesis and catalytic reaction optimization |
Manufacturing Quality Control of N-BOC-cis-4-fluoro-L-proline
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase HPLC with UV detection at 210 nm, comparing peak area to a certified reference standard. |
| Chiral Purity | Chiral HPLC | Separates enantiomers and diastereomers on a chiral stationary phase; (2S,4S) isomer peak area is compared to total stereoisomer peaks. |
| Residual Solvents | GC-FID | Detects and quantifies volatile organic solvents (e.g., ethyl acetate, methanol) by gas chromatography with flame ionization detection against calibration standards. |
| Water Content | Karl Fischer Titration | Measures water via coulometric or volumetric titration where iodine reacts stoichiometrically with water in anhydrous pyridine/methanol medium. |
| Heavy Metals | ICP-MS | Quantifies trace metal impurities (e.g., Pb, Cd, Ni) after acid digestion by measuring elemental mass-to-charge ratios with high sensitivity. |
| Residual Palladium | ICP-OES | Determines palladium from catalytic hydrogenation steps by plasma excitation and optical emission intensity measurement at characteristic wavelengths. |
| Appearance | Visual Inspection | Assesses physical state, color, and presence of visible particulates or discoloration against established reference standards under controlled lighting. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range at which solid transitions to liquid, indicating purity and identity via comparison to literature value (148-152 C). |
| Specific Optical Rotation | Polarimetry | Measures rotation of plane-polarized light by chiral compound in solution; confirms stereochemical integrity and concentration. |
| Related Substances | HPLC-UV (Forced Degradation) | Identifies and quantifies structurally related impurities (e.g., N-Boc deprotection product, epimerized isomers) using stressed samples and gradient HPLC. |
| Residue on Ignition | Gravimetric Analysis | Measures inorganic ash content after high-temperature incineration and weighing of residual non-volatile matter. |
| pH of Solution | pH Meter | Determines acidity/basicity of a standardized aqueous or aqueous-organic solution using calibrated glass electrode and reference electrode. |
Technical Specifications of N-BOC-cis-4-fluoro-L-proline
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Optical Rotation | -58.0 to -56.0 deg (c=1, in methanol) |
| Melting Point | 148 to 152 °C |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-BOC-cis-4-fluoro-L-proline
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-BOC-cis-4-fluoro-L-proline
Packaging of N-BOC-cis-4-fluoro-L-proline
Industrial N-BOC-cis-4-fluoro-L-proline Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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