N-BOC-4,4-difluoro-L-proline Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 203866-15-3 |
| Product name | N-BOC-4,4-difluoro-L-proline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for N-BOC-4,4-difluoro-L-proline
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-BOC-4,4-difluoro-L-proline Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-BOC-4,4-difluoro-L-proline
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Chiral fluorinated proline derivatives for synthesizing fluorinated peptides and protease inhibitors | Used as a key chiral building block; participates in amide bond coupling reactions after Boc deprotection in solid-phase or solution-phase peptide synthesis |
| Organic Synthesis | Precursor for constructing fluorinated heterocyclic scaffolds, applied in designing novel PROTAC molecules or targeted protein degraders | Undergoes structural modification via selective C–F bond activation in palladium-catalyzed cross-coupling or nucleophilic substitution reactions |
| Biochemical Research | Fluorinated amino acid component for fluorescent labeling probes or NMR tracers | Undergoes amino group coupling with fluorescent dyes or biotin derivatives following selective Boc deprotection |
Manufacturing Quality Control of N-BOC-4,4-difluoro-L-proline
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the sample's color and physical state (e.g., white to pale crystalline powder) under natural light or standard illumination to determine if it meets specifications. |
| Identification | Infrared Spectroscopy (IR) Nuclear Magnetic Resonance (¹H NMR) |
IR: Determine the infrared absorption spectrum of the sample and compare it with the standard spectrum to confirm characteristic functional groups (such as Boc group, C–F bond, etc.). ¹H NMR: Measure the hydrogen spectrum in deuterated solvent, and verify whether the chemical shifts and coupling constants of protons match the standard. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a reverse-phase C18 column, with an appropriate ratio of water-organic solvent (e.g., acetonitrile/methanol) as the mobile phase, and UV detection (typically 210–220 nm). Calculate the content of the main component using external standard method or area normalization method. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Use the same conditions as content determination or optimize the gradient elution program to separate and quantify potential impurities (such as de-Boc products, isomers, synthetic by-products), typically using peak area normalization method or the main component self-control method with correction factor. |
| Water Content | Karl Fischer Titration | Determine the moisture content of the sample using volumetric or coulometric methods, suitable for accurate measurement of trace moisture in fluorinated organic compounds. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection, with polar or non-polar capillary columns and FID detector. Detect residual organic solvents (such as dichloromethane, methanol, ethyl acetate, etc.) during synthesis according to ICH Q3C guidelines. |
| Specific Rotation | Polarimeter Method | Prepare a solution of specified concentration (usually in methanol or water), and measure the optical rotation at a specified wavelength (e.g., sodium D line, 589 nm) and temperature, then calculate the specific rotation to confirm L-configuration purity. |
| pH Value (if applicable) | pH Meter Method | Prepare a solution of the sample at a specified concentration in aqueous solution or suspension, and measure its pH value using a calibrated pH meter to assess the impact of acidic or basic impurities. |
| Melting Point | Capillary Melting Point Method | Determine the melting range from initial melting to complete melting using a melting point apparatus, serving as a supplementary indicator of physical purity. |
Technical Specifications of N-BOC-4,4-difluoro-L-proline
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 148-152°C |
| Optical Rotation | -51.0 to -47.0° (c=1, DMF) |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of N-BOC-4,4-difluoro-L-proline
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-BOC-4,4-difluoro-L-proline
Packaging of N-BOC-4,4-difluoro-L-proline
Industrial N-BOC-4,4-difluoro-L-proline Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply