N-Boc-cis-4-Fluoro-L-proline methyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 203866-16-4 |
| Product name | N-Boc-cis-4-Fluoro-L-proline methyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for N-Boc-cis-4-Fluoro-L-proline methyl ester
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk N-Boc-cis-4-Fluoro-L-proline methyl ester Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of N-Boc-cis-4-Fluoro-L-proline methyl ester
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Chiral intermediates for synthesizing fluorinated proline derivatives in targeted therapeutics (e.g., protease inhibitors, GPCR modulators) | Introduction and removal of protecting groups in multi-step organic synthesis; commonly applied in solid-phase peptide synthesis (SPPS) or solution-phase synthesis to construct fluorinated non-natural amino acid sequences |
| Biopharmaceuticals | Preparation of peptide-based candidate drugs containing 4-fluoro-L-proline to enhance metabolic stability and target-binding selectivity | Participation as a monomer in coupling reactions (e.g., DIC/HOBt or PyBOP activation) prior to peptide chain elongation, followed by Boc deprotection using TFA |
| Fine Chemicals | High-value chiral building blocks for developing novel fluorinated chiral catalysts or ligands | Structural modification reagent in asymmetric catalytic reactions; functionalized fluoroproline derivatives are obtained via derivatization steps including hydrolysis, reduction, and coupling |
Manufacturing Quality Control of N-Boc-cis-4-Fluoro-L-proline methyl ester
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 210 nm. |
| Chiral Purity | Chiral HPLC | Separation of enantiomers on a chiral stationary phase; quantification based on relative peak areas of target and impurity enantiomer. |
| Related Substances | HPLC-UV | Detection and quantification of structurally related impurities using gradient reversed-phase HPLC with UV detection. |
| Residual Solvents | GC-FID | Identification and quantification of volatile organic solvents by gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine generated in situ to react stoichiometrically with water. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, As) via inductively coupled plasma mass spectrometry after acid digestion. |
| Residual Palladium | ICP-MS | Specific quantification of palladium residues from catalytic steps using isotope-dilution ICP-MS. |
| Acid Value | Acid-Base Titration | Neutralization of free carboxylic acid groups with standardized NaOH solution using phenolphthalein indicator. |
| Optical Rotation | [alpha]D Measurement | Determination of specific rotation using a polarimeter at 20 degC with sodium D-line (589 nm) light. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed as the temperature range over which solid-to-liquid phase change occurs under controlled heating. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity versus angle to determine volume-based particle size distribution. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic microorganisms and absence testing for specified pathogens per pharmacopeial methods. |
Technical Specifications of N-Boc-cis-4-Fluoro-L-proline methyl ester
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow liquid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Optical Rotation | -67.0 ± 2.0° (c=1, in CHCl3) |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of N-Boc-cis-4-Fluoro-L-proline methyl ester
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of N-Boc-cis-4-Fluoro-L-proline methyl ester
Safety Information of N-Boc-cis-4-Fluoro-L-proline methyl ester
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of N-Boc-cis-4-Fluoro-L-proline methyl ester
Industrial N-Boc-cis-4-Fluoro-L-proline methyl ester Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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