FMOC-GLU(OTBU)-OH H2O Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 204251-24-1 |
| Product name | FMOC-GLU(OTBU)-OH H2O |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for FMOC-GLU(OTBU)-OH H2O
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk FMOC-GLU(OTBU)-OH H2O Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of FMOC-GLU(OTBU)-OH H2O
| Industry | Application | Process |
|---|---|---|
| Biopharmaceuticals | Protecting reagent for the glutamic acid side chain in solid-phase peptide synthesis | Used in Fmoc-based solid-phase peptide synthesis (SPPS) to selectively protect the γ-carboxyl group of L-glutamic acid, preventing side reactions during backbone coupling; the free glutamic acid residue is liberated upon cleavage of the tert-butyl ester with TFA and removal of the Fmoc group with piperidine |
| Pharmaceutical R&D | Key building block for peptide therapeutics and intermediates (e.g., GLP-1 analogues, antimicrobial peptides) | Employed as a chiral, orthogonally protected glutamic acid derivative in stepwise coupling or fragment condensation processes to maintain stereochemical integrity and ensure compatibility with side-chain functional groups |
| Fine Chemicals | Standard protected amino acid raw material for high-purity custom peptide synthesis services | Compatible with automated peptide synthesizers (e.g., Cyclone, Syro II), enabling amide bond formation in DMF/NMP solvents using activators such as HBTU, HATU, or DIC |
Manufacturing Quality Control of FMOC-GLU(OTBU)-OH H2O
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the sample's color, physical state (e.g., white to off-white powder), presence of agglomeration or impurities. |
| Purity (Main Component Content) | High-Performance Liquid Chromatography (HPLC) | Utilize a reversed-phase C18 column with UV detection (typically around 265 nm). Qualitative identification is based on retention time, while quantification is performed using area normalization or external standard method to assess the purity of the target compound. |
| Chiral Purity | Chiral High-Performance Liquid Chromatography (Chiral HPLC) | Use a chiral stationary phase column to detect the presence of D-isomer impurities and evaluate optical purity (ee value). |
| Moisture Content | Karl Fischer Titration | Available in either volumetric or coulometric mode. Accurately measures total water content including crystalline water and adsorbed water, suitable for quantitative analysis of monohydrate forms. |
| Residual Solvents | Gas Chromatography (GC) | Test for potentially residual organic solvents (e.g., dichloromethane, DMF, ethyl acetate) according to ICH guidelines, using appropriate detectors (e.g., FID). |
| Melting Point | Melting Point Apparatus Method | Determine the melting temperature range using capillary tube or automatic melting point instrument to assess homogeneity and purity of the substance. |
| Specific Rotation | Polarimeter Measurement | Measure the optical rotation under specified wavelength (e.g., sodium D line at 589 nm) and temperature, calculate specific rotation to verify optical activity. |
| Content (Titrations) | Acid-Base Titration | Titrate free carboxylic acid groups (e.g., using standardized NaOH solution) and calculate active ingredient content based on molecular structure (less commonly used for high-purity samples). |
| Confirmation of Hydrate/Water of Crystallization | Thermogravimetric Analysis (TGA) | Monitor mass loss during heating to confirm the presence of one molecule of crystalline water (approximately 3–5% weight loss). |
| Polymorphic Analysis | X-Ray Powder Diffraction (XRD) | Analyze characteristic diffraction peaks to confirm crystal structure consistency across batches, especially critical for polymorphic substances in quality control. |
| Infrared Spectroscopy (IR) | Fourier Transform Infrared Spectroscopy (FT-IR) | Compare absorption peaks of functional groups (e.g., aromatic rings, ester groups, carboxyl groups from Fmoc) with reference spectra for structural confirmation and impurity screening. |
| Nuclear Magnetic Resonance (NMR) | ¹H-NMR or ¹³C-NMR | Acquire proton or carbon spectra in deuterated solvents to confirm molecular structure, substitution positions, and identify impurity signals; commonly used for release testing or structural verification. |
Technical Specifications of FMOC-GLU(OTBU)-OH H2O
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -18.0 to -17.0 deg (c=1, DMF) |
| Melting Point | 148 to 152 °C |
| Identification (NMR) | Conforms to reference spectrum |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of FMOC-GLU(OTBU)-OH H2O
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of FMOC-GLU(OTBU)-OH H2O
Packaging of FMOC-GLU(OTBU)-OH H2O
Industrial FMOC-GLU(OTBU)-OH H2O Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply