D-PYROGLUTAMIC ACID TERT-BUTYL ESTER Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 205524-46-5 |
| Product name | D-PYROGLUTAMIC ACID TERT-BUTYL ESTER |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for D-PYROGLUTAMIC ACID TERT-BUTYL ESTER
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk D-PYROGLUTAMIC ACID TERT-BUTYL ESTER Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of D-PYROGLUTAMIC ACID TERT-BUTYL ESTER
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Chiral synthetic intermediate | Used in asymmetric synthesis of peptide-based therapeutics and β-lactam antibiotics as a key precursor for constructing chiral centers |
| Organic Synthesis | Protecting group reagent | Applied as a protecting group for the γ-carboxyl group of glutamic acid in amino acid synthesis to enable selective reaction control |
| Biochemistry | Drug development research | Employed in molecular design and synthesis of novel protease inhibitors and neuroactive compounds |
| Fine Chemicals | Preparation of high-value-added chemicals | Converted into other pyroglutamic acid derivatives via hydrolysis, esterification, or coupling reactions for functional molecule construction |
Manufacturing Quality Control of D-PYROGLUTAMIC ACID TERT-BUTYL ESTER
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and threshold limits per ICH Q3B. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., MTBE, heptane, methanol) against calibrated standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to measure trace water via stoichiometric reaction. |
| Optical Rotation | [alpha]D Measurement | Measurement of specific rotation using a polarimeter at 20 C and sodium D-line (589 nm) to confirm chiral integrity. |
| Heavy Metals | ICP-MS | Quantitative multi-element analysis after acid digestion; detection at sub-pptr levels per ICH Q3D guidelines. |
| Chloride Impurity | Ion Chromatography | Separation and conductivity detection of chloride anion in aqueous extract; quantified against NaCl calibration curve. |
| Residual tert-Butyl Alcohol | GC-FID | Direct injection GC-FID analysis with internal standard (e.g., isopropanol) for accurate quantification. |
| Acid Value | Acid-Base Titration | Titration with standardized KOH in ethanol/isopropanol mixture using phenolphthalein indicator to determine free acid content. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, per USP <741>. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity against established reference standards under controlled lighting. |
| Particle Size Distribution | Laser Diffraction | Dry dispersion and measurement of size distribution by light scattering intensity pattern analysis. |
Technical Specifications of D-PYROGLUTAMIC ACID TERT-BUTYL ESTER
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 78–82°C |
| Optical Rotation | -15.0 to -19.0° (c=1, in CHCl3) |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of D-PYROGLUTAMIC ACID TERT-BUTYL ESTER
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of D-PYROGLUTAMIC ACID TERT-BUTYL ESTER
Safety Information of D-PYROGLUTAMIC ACID TERT-BUTYL ESTER
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of D-PYROGLUTAMIC ACID TERT-BUTYL ESTER
Industrial D-PYROGLUTAMIC ACID TERT-BUTYL ESTER Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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