4-Amino-5-bromo-2-chloropyrimidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 205672-25-9 |
| Product name | 4-Amino-5-bromo-2-chloropyrimidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Amino-5-bromo-2-chloropyrimidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Amino-5-bromo-2-chloropyrimidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Amino-5-bromo-2-chloropyrimidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for synthesis of antitumor agents | Produced via regioselective bromination of 4-amino-2-chloropyrimidine with a brominating reagent (e.g., NBS) |
| Pharmaceuticals | Intermediate for synthesis of kinase inhibitors | Used as a nitrogen-containing heterocyclic scaffold to introduce aryl or heteroaryl substituents via palladium-catalyzed cross-coupling reactions |
| Agrochemicals | Intermediate for synthesis of novel fungicides | Used to construct the core structure of active molecules via nucleophilic substitution to introduce amino or alkoxy side chains |
| Chemical Research | Building block for synthesis of complex heterocyclic compounds | Used as a multifunctional aromatic heterocyclic substrate in reactions including Ullmann coupling and Buchwald–Hartwig amination |
Manufacturing Quality Control of 4-Amino-5-bromo-2-chloropyrimidine
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the sample's color, physical state (e.g., white to off-white crystalline powder) and presence of foreign matter with the naked eye to determine compliance with quality specifications. |
| Identification | Infrared Spectroscopy (IR) High-Performance Liquid Chromatography (HPLC) |
IR: Measure the infrared absorption spectrum of the sample and compare it with that of the reference standard to confirm characteristic functional groups (e.g., amino, chlorine, bromine substituted pyrimidine ring); HPLC: Compare retention times of the sample and reference standard under specific chromatographic conditions to confirm identity. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with mobile phases such as methanol-water or acetonitrile-buffer salt, detect with UV detector (typically around 254 nm), and calculate the main component content using external standard method, ensuring purity meets requirements (e.g., ≥98.0%). |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Utilize gradient or isocratic elution programs to separate and detect potential process impurities and degradation products (e.g., unreacted starting materials, dehalogenation by-products), controlling individual and total impurity levels using area normalization or corrected factor methods. |
| Water Content | Karl Fischer Titration | Determine moisture content using either the volumetric or coulometric Karl Fischer method, suitable for moisture-sensitive organic compounds, ensuring water content remains within specified limits (e.g., ≤0.5%). |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection with polar or non-polar capillary columns and FID detection to identify and quantify organic solvents (e.g., methanol, dichloromethane, DMF) potentially remaining from synthesis, following ICH Q3C guidelines for acceptable limits. |
| Melting Point | Capillary Melting Point Method | Fill the sample into a melting point capillary tube and heat slowly in a melting point apparatus, recording the temperature range from initial melting to complete melting, comparing with literature values (e.g., approximately 168–172 °C) to assess purity and crystal form consistency. |
| Heavy Metals | Thioacetamide Method (Colorimetry) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Conducted according to general pharmacopoeia procedures, detecting total heavy metals (e.g., lead, cadmium, mercury, arsenic) via colorimetric reaction or high-sensitivity instrumental analysis, ensuring compliance with safety limit requirements. |
Technical Specifications of 4-Amino-5-bromo-2-chloropyrimidine
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.0% (by LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 148–152°C |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Conforms to reference spectrum |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Amino-5-bromo-2-chloropyrimidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Amino-5-bromo-2-chloropyrimidine
Safety Information of 4-Amino-5-bromo-2-chloropyrimidine
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-Amino-5-bromo-2-chloropyrimidine
Industrial 4-Amino-5-bromo-2-chloropyrimidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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