9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 206184-49-8 |
| Product name | 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Antiviral drug research | Used as a nucleoside analog in the synthesis of antiviral active compounds, particularly for developing inhibitors targeting DNA viruses such as hepatitis B virus (HBV) and herpes simplex virus (HSV) |
| Biochemistry | Molecular probe and labeling studies | Applied to construct bioprobes with specific recognition functionality; employed in experimental simulation of phosphorylation metabolic pathways |
| Pharmaceutical intermediates | Nucleoside-based drug precursors | Serves as a key intermediate in multistep organic synthesis for preparing antiviral candidate drugs containing the phosphonylmethoxypropyl structural motif |
| Laboratory research | Drug metabolism and pharmacokinetic analysis | Used in new drug evaluation workflows, including in vitro enzymatic metabolic stability testing, cellular permeability assessment, and identification of active metabolites |
Manufacturing Quality Control of 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identification | Infrared Spectroscopy (IR) | Determine the infrared absorption spectrum of the sample and compare it with standard spectra to confirm the presence of characteristic functional groups (such as P=O, C–N, adenine ring), used for structural confirmation. |
| Identification | Proton Nuclear Magnetic Resonance (¹H NMR) | Analyze the chemical shifts, coupling constants, and integral areas of hydrogen atoms using nuclear magnetic resonance to verify the molecular structure, especially the stereochemistry and connection pattern of the (R)-2-(phosphonomethoxy)propyl group. |
| Identification | Mass Spectrometry (MS) | Use electrospray ionization (ESI-MS) or MALDI-TOF techniques to determine the molecular ion peak, confirming the molecular weight and fragment information, which assists in structural identification. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column with a mobile phase consisting of phosphate buffer and organic solvents (e.g., methanol or acetonitrile), and a UV detector (typically around 260 nm) for detection. Calculate the content of the main component using external standard or area normalization methods. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Similar to content determination, but optimized chromatographic conditions are used to achieve good separation between the main peak and potential impurities (such as isomers, degradation products, synthetic intermediates). Quantification is performed using self-comparison method or self-comparison method with correction factors. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection with DB-624 or similar polar capillary columns and FID detector to detect possible residual organic solvents (such as methanol, ethanol, dichloromethane) according to pharmacopoeia regulations. |
| Dry Loss | Thermogravimetric Analysis (TGA) or Constant Pressure Drying Method | Dry at a specified temperature (e.g., 105°C) until constant weight is achieved, measure the mass loss to evaluate the water content and volatile components; combined with the properties of monohydrate, ensure the dry loss range conforms to the theoretical crystalline water ratio. |
| Moisture | Karl Fischer Titration | Determine the moisture content precisely using volumetric or coulometric methods. Verify whether it is a monohydrate (theoretical water content about 5.3%) and monitor changes in moisture during production. |
| Specific Rotation | Polarimetry | Prepare a solution of a certain concentration and measure the optical rotation at a specified wavelength (usually the sodium D line, 589 nm) and temperature to calculate specific rotation, used to confirm the purity of the (R)-configuration and optical purity. |
| pH Value | pH Meter Measurement | Determine the pH value by preparing a solution of the sample at a specified concentration using a calibrated pH meter, reflecting its acidic-basic nature and possible degradation. |
| Ignition Residue / Ash Content | Ignition Residue Determination | Weigh the remaining inorganic substances after high-temperature ignition of the sample to control the total amount of inorganic impurities. |
| Heavy Metals | Atomic Absorption Spectrometry (AAS) or Inductively Coupled Plasma Mass Spectrometry (ICP-MS) | Determine the residue of harmful elements such as lead, arsenic, cadmium, and mercury after digesting the sample, ensuring compliance with pharmaceutical safety limits. |
Technical Specifications of 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Melting Point | 178–182°C |
| Optical Rotation | +12.0 to +14.0° (c=1, in water) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate
Safety Information of 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate
Industrial 9-[(R)-2-(Phosphonomethoxy)propyl]adenine monohydrate Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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