2,5-Difluoromandelic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 207853-61-0 |
| Product name | 2,5-Difluoromandelic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2,5-Difluoromandelic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2,5-Difluoromandelic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2,5-Difluoromandelic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral intermediates for synthesizing sitagliptin derivatives (antidiabetic agents) | Asymmetric hydrogenation or enzymatic reduction of 2,5-difluoroacetophenone to produce the key chiral alcohol intermediate, followed by oxidation and hydrolysis to construct the mandelic acid structure |
| Agrochemicals | Structural building block for novel fluorinated insecticides and fungicides | Used as a fluorinated aryl chiral synthon in coupling reactions (e.g., Suzuki, Heck) to introduce bioactive side chains, thereby optimizing target binding affinity and metabolic stability |
| Materials Science | Chiral modulator for liquid crystal monomers and organic optoelectronic materials | After esterification or amidation, incorporated into the core structure of liquid crystal molecules to tune the mesophase temperature range and birefringence |
Manufacturing Quality Control of 2,5-Difluoromandelic acid
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reversed-phase HPLC with UV detection at 210-230 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV against qualified reference standards or threshold-based reporting. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., methanol, ethyl acetate, toluene) based on calibrated external standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine generation in pyridine-free reagent to determine water by stoichiometric reaction. |
| Heavy Metals | ICP-MS | Multi-element quantification of Pb, Cd, Hg, As, and other regulated metals after acid digestion and matrix-matched calibration. |
| Chloride Impurity | Ion Chromatography | Separation and conductivity detection of chloride ions in aqueous extract, calibrated with NaCl standards. |
| Sulfated Ash | Gravimetric Analysis | Ignition at 500-600 C followed by weighing of non-volatile inorganic residue after sulfuric acid treatment. |
| Optical Rotation | [alpha]D Measurement | Determination of specific optical rotation using sodium D-line light in solution at specified concentration and temperature. |
| Melting Point | Capillary Melting Point Apparatus | Thermal determination of solid-to-liquid transition range using calibrated capillary method per USP <741>. |
| pH of Aqueous Solution | Potentiometric pH Measurement | Measurement of hydrogen ion activity in saturated aqueous suspension using calibrated glass electrode system. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersed sample via light scattering pattern to calculate volume-based particle size distribution. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic mesophilic microorganisms and detection of specified pathogens using selective culture media and incubation. |
Technical Specifications of 2,5-Difluoromandelic acid
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Melting Point | 142.0 - 146.0 °C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Residue on Ignition | <=0.1% |
| Optical Rotation | -15.0 to -19.0 ° (c=1, in methanol) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2,5-Difluoromandelic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Packaging of 2,5-Difluoromandelic acid
Industrial 2,5-Difluoromandelic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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