4-Chloro-3-nitrocinnamic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 20797-48-2 |
| Product name | 4-Chloro-3-nitrocinnamic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Chloro-3-nitrocinnamic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Chloro-3-nitrocinnamic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Chloro-3-nitrocinnamic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key intermediate for synthesizing antimalarial drugs chloroquine and hydroxychloroquine | Used in multi-step synthesis of chloroquine-class drugs involving reduction, cyclization, and chlorination |
| Agrochemical Intermediates | Used to synthesize novel insecticides and fungicides | Serves as a heterocyclic building block in coupling or cycloaddition reactions |
| Organic Synthesis | Precursor for fluorescent dyes and optical materials | Functionalized via esterification, amidation, or metal-catalyzed coupling reactions |
Manufacturing Quality Control of 4-Chloro-3-nitrocinnamic acid
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 254 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and relative response factors. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common organic solvents (e.g., methanol, ethyl acetate) per ICH Q3C guidelines. |
| Moisture Content | Karl Fischer Titration | Volumetric or coulometric titration with iodine-based reagent to determine water content based on stoichiometric reaction with water. |
| Heavy Metals | ICP-OES | Multi-element quantification of Pb, Cd, Hg, As, and other heavy metals after acid digestion, using inductively coupled plasma optical emission spectroscopy. |
| Chloride Content | Potentiometric Titration | Titration with silver nitrate using a silver indicator electrode; endpoint detected by potential change due to AgCl precipitation. |
| Nitro Group Content | Reduction-Titration (Zn/HCl + NaOH back-titration) | Reduction of nitro group to ammonium salt followed by alkaline distillation and titration of liberated ammonia. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, indicating purity and identity via comparison to reference value. |
| Appearance | Visual Inspection | Assessment of physical state, color, and presence of foreign particles under controlled white light and against specified standards. |
| pH of Aqueous Suspension | pH Meter | Measurement of pH in a defined suspension (e.g., 1% w/v in water) using calibrated pH electrode to assess acidic impurities or degradation. |
| Loss on Drying | Gravimetric Analysis (Oven Drying) | Weight loss after drying at specified temperature (e.g., 105 C) for fixed duration, reflecting volatile and moisture content. |
| Residue on Ignition | Sulfated Ash Gravimetry | Weighing residue after high-temperature incineration following sulfuric acid treatment, indicating inorganic impurities. |
Technical Specifications of 4-Chloro-3-nitrocinnamic acid
| Test Item | Specification |
|---|---|
| Appearance | Off-White to Yellow to Tan Powder or Solid |
| Purity | >=98.0% (LC-MS) |
| Melting Point | 162–166 °C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Chloro-3-nitrocinnamic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Chloro-3-nitrocinnamic acid
Safety Information of 4-Chloro-3-nitrocinnamic acid
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-Chloro-3-nitrocinnamic acid
Industrial 4-Chloro-3-nitrocinnamic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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