2-(1-Piperazinyl)pyrimidine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 20980-22-7 |
| Product name | 2-(1-Piperazinyl)pyrimidine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2-(1-Piperazinyl)pyrimidine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-(1-Piperazinyl)pyrimidine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-(1-Piperazinyl)pyrimidine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate for central nervous system (CNS) drugs, used in the synthesis of antidepressants, anxiolytics, and 5-HT receptor modulators (e.g., analogues of nefazodone) | Employed as a key nitrogen-containing heterocyclic building block in multistep coupling reactions (e.g., Suzuki and Buchwald–Hartwig cross-couplings), followed by hydrochloride salt formation and purification |
| Agrochemicals | Structural modification unit for novel insecticides and plant growth regulators | Integrated as a pyrimidine–piperazine heterocycle to enhance selective binding affinity toward insect nicotinic acetylcholine receptors (nAChRs) |
| Materials Science | Functional component in hole-transport materials for organic light-emitting diodes (OLEDs) | After N-alkylation or N-arylation, incorporated as an electron-donating unit into conjugated polymer backbones or applied as an interfacial modification layer |
Manufacturing Quality Control of 2-(1-Piperazinyl)pyrimidine
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Identification Test | Infrared Spectroscopy (IR) | Determine the infrared absorption spectrum of the sample and compare it with standard spectra to confirm characteristic functional groups of 1-(2-pyrimidinyl)piperazine, such as N–H, C=N, and C–N absorption peaks. |
| Proton Nuclear Magnetic Resonance (¹H NMR) | Analyze the chemical shifts, integration areas, and coupling constants of hydrogen atoms using nuclear magnetic resonance to verify structural features, such as protons on the piperazine ring and pyrimidine ring. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 chromatographic column with an appropriate ratio of water-organic solvent (e.g., methanol or acetonitrile) as the mobile phase. Detect using a UV detector (typically at 254 nm), and quantify the main component using external or internal standard methods. |
| Related Substances (Impurities) Check | High-Performance Liquid Chromatography (HPLC) | Use gradient or isocratic elution procedures to separate and detect possible process impurities or degradation products. Evaluate the impurity level using peak area normalization or reference substance methods. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace or direct injection with capillary columns and FID detector to perform qualitative and quantitative analysis of residual organic solvents (e.g., methanol, dichloromethane, ethanol) from the synthesis process. |
| Dry Loss | Thermogravimetric Analysis (TGA) or Constant-Temperature Drying Method | Dry the sample to constant weight at a specified temperature (e.g., 105°C) and measure the percentage of mass loss due to moisture or other volatile components. |
| Melting Point | Capillary Melting Point Determination | Determine the temperature range from initial melting to complete melting using a melting point apparatus, serving as an auxiliary indicator for purity and identity. |
| pH Value | pH Meter Method | Prepare a certain concentration solution (e.g., 1% aqueous solution) and measure its acidity or alkalinity using a calibrated pH meter, reflecting the free base or salt form and potential effects of impurities. |
| Moisture | Karl Fischer Titration | Accurately determine the moisture content using volumetric or coulometric Karl Fischer titration, suitable for quality control of moisture-sensitive bulk drugs. |
Technical Specifications of 2-(1-Piperazinyl)pyrimidine
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (HPLC) |
| Melting Point | 58-62°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2-(1-Piperazinyl)pyrimidine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-(1-Piperazinyl)pyrimidine
Packaging of 2-(1-Piperazinyl)pyrimidine
Industrial 2-(1-Piperazinyl)pyrimidine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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