2,4,5-Trifluorophenylacetic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 209995-38-0 |
| Product name | 2,4,5-Trifluorophenylacetic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2,4,5-Trifluorophenylacetic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2,4,5-Trifluorophenylacetic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2,4,5-Trifluorophenylacetic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key chiral intermediate for the synthesis of the antidiabetic drug sitagliptin | Prepared via asymmetric hydrogenation or enzymatic reduction of 2,4,5-trifluoroacetanilide to (S)-2,4,5-trifluorophenylacetic acid, followed by amidation and coupling steps to construct the sitagliptin molecular scaffold |
| Agrochemicals | Structural building block for novel fluorinated herbicides and fungicides | Introduced as a fluorinated aryl moiety into heterocyclic cores (e.g., triazoles, pyrimidines) to enhance lipophilicity and target-binding activity; commonly employed in Suzuki coupling or nucleophilic substitution reactions for C–C bond formation |
| Materials Science | Fluorinated modification component for high-performance liquid crystal monomers and organic optoelectronic materials | Attached to rigid cores (e.g., biphenyl, pyrimidine) via esterification or amidation to modulate mesophase transition temperature and birefringence; used in TFT-LCD liquid crystal mixture formulations |
Manufacturing Quality Control of 2,4,5-Trifluorophenylacetic acid
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Using a reversed-phase C18 chromatographic column, with methanol/water or acetonitrile/water containing a low concentration of acid (such as phosphoric acid or formic acid) as the mobile phase, and a UV detector (approximately 230–260 nm) to detect the main component. Quantification is performed using an external standard method. |
| Purity Analysis | Gas Chromatography-Mass Spectrometry (GC-MS) | Applicable for volatile derivatives (such as methyl esters), using gas chromatography for separation combined with mass spectrometry for qualitative and semi-quantitative analysis of impurities, thereby assessing sample purity. |
| Structure Confirmation | Nuclear Magnetic Resonance Spectroscopy (NMR) | Using ¹H NMR and ¹⁹F NMR to confirm the structure of the compound, verifying the position of fluorine substitution and the splitting pattern of aromatic protons to match the characteristics of 2,4,5-trifluorophenylacetic acid. |
| Impurity Testing | High-Performance Liquid Chromatography-Mass Spectrometry (LC-MS) | Combining the separation capability of HPLC with the sensitivity of mass spectrometry to identify and qualitatively analyze possible organic impurities (such as intermediates, by-products, or degradation products). |
| Residual Solvents | Gas Chromatography (GC) | Detecting residual organic solvents (such as methanol, ethanol, dichloromethane, etc.) during production according to pharmacopoeia methods (e.g., ICH Q3C), using headspace sampling and a FID detector. |
| Acid Value / Functional Group Verification | Titration Method (Acid-Base Titration) | Titration of carboxylic groups using a standard NaOH solution in non-aqueous or aqueous medium, calculating the acid value to verify the presence and content of the —COOH functional group. |
| Moisture Content | Karl Fischer Method (Karl Fischer) | Accurately determining the moisture content of the sample using electrochemical reaction, divided into volumetric method (suitable for high moisture content) and coulometric method (suitable for trace moisture). |
| Polymorphic Analysis (if applicable) | X-ray Diffraction (XRD) | If the compound exhibits polymorphism, XRD can be used to analyze its crystal structure, for quality consistency control. |
| Melting Point Determination | Melting Point Apparatus Method | Determining the melting point range using a capillary method to assess the purity and consistency of the substance; pure substances usually have a sharp melting point. |
| Appearance and Color | Visual Inspection | Observing the color, state (white to off-white powder), and presence of visible foreign matter under specified lighting conditions. |
Technical Specifications of 2,4,5-Trifluorophenylacetic acid
| Test Item | Specification |
|---|---|
| Appearance | White crystalline solid |
| Purity | >=98.0% (by LC-MS) |
| Melting Point | 124–128°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=10 ppm |
| Residue on Ignition | <=0.1% |
| Acid Value (mg KOH/g) | 210–225 mg KOH/g |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2,4,5-Trifluorophenylacetic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2,4,5-Trifluorophenylacetic acid
Safety Information of 2,4,5-Trifluorophenylacetic acid
| Pictograms |  |
| Signal Word | Danger |
| Safety Data Sheet | |
Packaging of 2,4,5-Trifluorophenylacetic acid
Industrial 2,4,5-Trifluorophenylacetic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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