4-Bromo-2-fluorobenzenesulfonamide Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 214210-30-7 |
| Product name | 4-Bromo-2-fluorobenzenesulfonamide |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Bromo-2-fluorobenzenesulfonamide
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Bromo-2-fluorobenzenesulfonamide Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Bromo-2-fluorobenzenesulfonamide
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Pharmaceutical Intermediates | Serves as a key building block in the synthesis of tyrosine kinase inhibitors (e.g., JAK inhibitors) and other targeted therapeutics, enabling construction of bioactive molecular scaffolds containing sulfonamide motifs. |
| Pharmaceutical Chemicals | Active Pharmaceutical Ingredient (API) Synthesis | Introduces specific fluorine and bromine substituents via nucleophilic substitution at the sulfonamide group or cross-coupling reactions (e.g., Suzuki coupling) on the aromatic ring to modulate metabolic stability and bioavailability. |
| Organic Synthesis | Organic Synthesis Building Block | Enables carbon–carbon or carbon–heteroatom bond formation through transition-metal-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Buchwald–Hartwig) leveraging the reactivity of the bromine atom to construct complex aromatic compounds. |
| Research Reagents | Chemical Biology Research | Used as a probe molecule to screen enzyme inhibitors or receptor ligands with specific sulfonamide-binding capability, facilitating studies of biomolecular target–ligand interactions. |
Manufacturing Quality Control of 4-Bromo-2-fluorobenzenesulfonamide
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase HPLC with UV detection at 254 nm, based on peak area comparison against reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies impurities (e.g., isomers, des-bromo, hydrolysis products) using gradient HPLC-UV with suitable column and mobile phase. |
| Residual Solvents | GC-FID | Measures trace organic solvents (e.g., methanol, toluene, DMF) by headspace GC with flame ionization detection. |
| Water Content | Karl Fischer Titration | Determines water by coulometric or volumetric titration using iodine generated electrochemically or added reagent, based on stoichiometric reaction with water. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, Hg, Ni) after acid digestion using inductively coupled plasma mass spectrometry for ultra-trace sensitivity. |
| Chloride Impurity | Ion Chromatography | Separates and quantifies chloride ions using suppressed conductivity detection after aqueous extraction and filtration. |
| Sulfate Impurity | Ion Chromatography | Separates and quantifies sulfate ions using suppressed conductivity detection following sample dissolution and dilution. |
| Residue on Ignition | Gravimetric Analysis | Measures non-volatile inorganic residue after charring and ashing at 700-800 C, followed by precise weighing. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using calibrated capillary apparatus per USP <741>. |
| Appearance | Visual Inspection | Assesses physical state, color, and homogeneity against established reference standards under controlled lighting conditions. |
| Particle Size Distribution | Laser Diffraction | Measures particle size distribution in dry or dispersed state using Mie scattering theory and laser diffraction principle. |
| Bulk Density | Tap Density Tester | Determines mass per unit volume after standardized tapping per USP <616>, reflecting powder flow and packing behavior. |
Technical Specifications of 4-Bromo-2-fluorobenzenesulfonamide
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (LC-MS) |
| Melting Point | 142–146°C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Bromo-2-fluorobenzenesulfonamide
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Bromo-2-fluorobenzenesulfonamide
Safety Information of 4-Bromo-2-fluorobenzenesulfonamide
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-Bromo-2-fluorobenzenesulfonamide
Industrial 4-Bromo-2-fluorobenzenesulfonamide Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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