4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 214342-63-9 |
| Product name | 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Synthesis of active pharmaceutical ingredients (APIs), including antitumor agents and kinase inhibitors | Serves as a key intermediate in coupling reactions (e.g., Suzuki, Heck) or nucleophilic substitution reactions to construct the core pyridone scaffold of drug molecules |
| Agrochemical R&D | Structural modification and lead compound optimization for novel insecticides and fungicides | Enables functional group transformation via the bromine atom to introduce pharmacophores—such as fluorinated groups, cyano groups, or heteroaryl moieties—to enhance biological activity and selectivity |
| Organic Synthesis | Multifunctional heterocyclic building block for constructing complex nitrogen-containing heterocycles | Undergoes metallation (e.g., with n-BuLi) followed by reaction with electrophiles, or serves as a substrate in palladium-catalyzed cross-coupling to prepare 2-substituted-1-methylpyridin-4-one derivatives |
Manufacturing Quality Control of 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by comparison of peak area against a certified reference standard using reversed-phase chromatography and UV detection at 254 nm. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC with UV detection; identification based on retention time matching and relative response factors. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents (e.g., methanol, ethyl acetate) based on calibrated external standards. |
| Water Content | Karl Fischer Titration | Electrochemical titration using iodine generated in situ to determine water content via stoichiometric reaction with pyridine and methanol in the reagent. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, As) after acid digestion, using mass spectrometry for high sensitivity and isotopic resolution. |
| Chloride Impurity | Ion Chromatography | Separation of chloride anions on an anion-exchange column with suppressed conductivity detection and quantification against chloride standard calibration. |
| Sulfated Ash | Gravimetric Analysis | Incineration at 700-800 C followed by weighing of non-volatile inorganic residue after treatment with sulfuric acid. |
| Optical Rotation | [alpha]D Measurement | Determination of specific rotation using a polarimeter at 20 C with sodium D-line (589 nm) to confirm chiral integrity and absence of racemization. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed as temperature range of solid-to-liquid phase change using calibrated capillary apparatus per USP <741>. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity versus angle to calculate volume-based particle size distribution in suspension medium. |
| Bulk Density | Graduated Cylinder Method | Mass per unit volume measured by gently pouring sample into a calibrated cylinder and recording settled volume per ASTM D1895. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic mesophilic microorganisms using membrane filtration followed by incubation on soybean-casein digest agar per USP <61>. |
Technical Specifications of 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
| Test Item | Specification |
|---|---|
| Appearance | Off-white solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 148–152°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
Safety Information of 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE
Industrial 4-BROMO-1-METHYLPYRIDIN-2(1H)-ONE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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