(S)-2-(piperazin-2-yl)acetonitrile dihydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 2158301-19-8 |
| Product name | (S)-2-(piperazin-2-yl)acetonitrile dihydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeReagent Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (S)-2-(piperazin-2-yl)acetonitrile dihydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (S)-2-(piperazin-2-yl)acetonitrile dihydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (S)-2-(piperazin-2-yl)acetonitrile dihydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Experimental antitumor drug candidate compound targeting specific kinases (e.g., BTK, EGFR mutants) | Synthesis and screening of lead compounds for preclinical pharmacological studies and structure–activity relationship (SAR) optimization |
| Pharmaceutical R&D | Highly selective kinase inhibitor tool molecule for target validation and signaling pathway mechanistic studies | Kinase activity assays at the cellular level (e.g., HTRF, ADP-Glo) and Western blot confirmation of downstream protein phosphorylation inhibition |
| Chemical Research | Key intermediate for constructing novel pyridopyrimidine heterocyclic scaffolds | Multi-step organic synthesis including palladium-catalyzed cross-coupling (e.g., Suzuki, Heck reactions), cyclization–condensation, and N-alkylation modifications |
Manufacturing Quality Control of (S)-2-(piperazin-2-yl)acetonitrile dihydrochloride
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe sample color, physical form (e.g., white crystalline powder), presence of foreign matter, or clumping due to moisture absorption. |
| Identification | Infrared Spectroscopy (IR) | Compare characteristic absorption peaks with standard spectra to confirm functional groups and molecular framework consistency. |
| High-Performance Liquid Chromatography (HPLC) | Retention time matches that of the reference standard, used for preliminary identification. | |
| Mass Spectrometry (MS) / Nuclear Magnetic Resonance (NMR) | Precisely determine molecular weight or analyze proton/carbon spectra to confirm chemical structure (commonly used in R&D or registration phases). | |
| Assay | High-Performance Liquid Chromatography with UV Detection (HPLC-UV) | Use external standard method or area normalization method to quantify the main component content (typically requires ≥98.0% or as per specification). |
| Related Substances / Impurities | HPLC-UV (Gradient Elution) | Separate and quantify process-related impurities and degradation products; set impurity limits (e.g., individual impurity ≤0.1%, total impurities ≤0.5%). |
| Residual Solvents | Gas Chromatography with Flame Ionization Detection (GC-FID) / Headspace GC (HS-GC) | Headspace or direct injection to detect residual organic solvents from synthesis (e.g., methanol, ethyl acetate, DMF, etc.). |
| Loss on Drying | Drying Method (105°C) | Weigh sample before and after drying to calculate moisture and volatile content (typically ≤0.5%). |
| Residue on Ignition | High-Temperature Ashing Method (600–800°C) | Determine total inorganic salts or metal residue (typically ≤0.1%). |
| Heavy Metals | Inductively Coupled Plasma Mass Spectrometry (ICP-MS) or Atomic Absorption Spectroscopy (AAS) | Detect elemental impurities such as lead, cadmium, mercury, arsenic, meeting ICH Q3D or pharmacopoeia limits. |
| pH (if solution) | pH Meter | Prepare aqueous solution at specified concentration and measure pH to assess stability or suitability. |
| Melting Point | Capillary Melting Point Apparatus | Determine melting temperature range to assist in identification and purity assessment (for solids). |
| Specific Optical Rotation (if chiral) | Polarimeter | For optically active compounds, measure optical rotation at a specific wavelength to control enantiomeric purity. |
| Particle Size Distribution (if required) | Laser Particle Size Analyzer | Control particle size affecting solubility or formulation performance (especially for API used in solid dosage forms). |
Technical Specifications of (S)-2-(piperazin-2-yl)acetonitrile dihydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 142–146°C |
| Identification (NMR) | Consistent with structure |
| Optical Rotation | -4.0 to -3.0 (c=1, in methanol) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (S)-2-(piperazin-2-yl)acetonitrile dihydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (S)-2-(piperazin-2-yl)acetonitrile dihydrochloride
Safety Information of (S)-2-(piperazin-2-yl)acetonitrile dihydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of (S)-2-(piperazin-2-yl)acetonitrile dihydrochloride
Industrial (S)-2-(piperazin-2-yl)acetonitrile dihydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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