M-NIFEDIPINE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 21881-77-6 |
| Product name | M-NIFEDIPINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for M-NIFEDIPINE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk M-NIFEDIPINE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of M-NIFEDIPINE
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate for the calcium channel blocker nitrendipine | Prepared via multi-step organic synthesis, including nitro group reduction and cyclization |
| Chemical Synthesis | Used to construct the 1,4-dihydropyridine scaffold | Classical or modified Hantzsch dihydropyridine synthesis |
| Drug Discovery | Structural template for screening lead compounds targeting cardiovascular diseases | Structure–activity relationship (SAR)-driven structural modification and biological activity evaluation |
Manufacturing Quality Control of M-NIFEDIPINE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification by peak area comparison against a certified reference standard using reversed-phase chromatography and UV detection at 254 nm. |
| Related Substances | HPLC-UV | Separation and quantification of impurities relative to the main peak using gradient HPLC with UV detection. |
| Residual Solvents | GC-FID | Headspace gas chromatography with flame ionization detection to quantify volatile organic solvents based on calibrated response factors. |
| Water Content | Karl Fischer Titration | Volumetric titration using iodine generated electrochemically in pyridine-methanol solvent system; water reacts stoichiometrically with iodine and sulfur dioxide. |
| Heavy Metals | ICP-OES | Multi-element quantification after acid digestion by measuring atomic emission intensities at characteristic wavelengths. |
| Chloride Impurity | Ion Chromatography | Separation of anions on an ion-exchange column followed by conductivity detection; chloride is quantified against calibration standards. |
| Sulfated Ash | Gravimetric Analysis | Ignition of sample at 700-800 C after sulfuric acid treatment; residual inorganic ash is weighed following standardized calcination. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed as the temperature range over which solid-to-liquid phase change occurs under controlled heating rate. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light passing through a solution; indicates chiral purity if applicable (though compound is achiral, used for trace chiral contaminants). |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity patterns to determine volume-based particle size distribution in a dispersed slurry. |
| Bulk Density | USP <616> Tap Density Test | Determination of mass per unit volume after mechanical tapping of a powder sample in a graduated cylinder. |
| Microbial Limits | Membrane Filtration and Plate Count | Sample filtration followed by incubation on selective agar media; enumeration of aerobic bacteria, yeasts, and molds per pharmacopeial guidelines. |
Technical Specifications of M-NIFEDIPINE
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=98.0% (by LC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Melting Point | 148–152 °C |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Conforms to reference standard |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of M-NIFEDIPINE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of M-NIFEDIPINE
Packaging of M-NIFEDIPINE
Industrial M-NIFEDIPINE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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