7-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 220247-73-4 |
| Product name | 7-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 7-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 7-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 7-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Chemicals | Key Intermediate | Used in the synthesis of antiarrhythmic drugs such as vernakalant. As the core scaffold of isoquinoline derivatives, it participates in constructing the tetrahydroisoquinoline moiety of the drug molecule. |
| Pharmaceutical Chemicals | Drug Discovery Building Block | Serves as a structural unit for constructing diverse bioactive molecules. The bromine atom retained in its structure enables further functionalization via cross-coupling reactions, including Suzuki and Buchwald–Hartwig couplings. |
| Organic Synthesis | Synthesis of Nitrogen-Containing Heterocycles | Used as a starting material to synthesize 7-bromoisoquinoline via dehydrogenation, or to prepare N-substituted tetrahydroisoquinoline derivatives for screening potential pharmacological activity. |
Manufacturing Quality Control of 7-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 254 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time relative to reference standards or threshold reporting. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., methanol, ethyl acetate, toluene) against calibrated standards. |
| Water Content | Karl Fischer Titration | Electrochemical titration using iodine generation in pyridine-free reagent; water reacts stoichiometrically with iodine and sulfur dioxide in methanol medium. |
| Heavy Metals | ICP-MS | Multi-element quantification of Pb, Cd, Hg, As, and others after acid digestion, using isotopic detection with high sensitivity and low detection limits. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride ions using anion-exchange column with suppressed conductivity detection. |
| Residue on Ignition | Gravimetric Analysis | Mass measurement before and after high-temperature ashing (700-800 C) to determine inorganic residue content. |
| Optical Rotation | Polarimetry | Measurement of specific rotation using sodium D-line light; indicates chiral purity and absence of racemization. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range over which solid transitions to liquid, indicating crystallinity and purity. |
| pH of Aqueous Solution | Potentiometric pH Measurement | Measurement using calibrated glass electrode in a defined aqueous suspension or solution to assess acidity from residual HCl or degradation. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity vs. angle to calculate volume-based particle size distribution in dispersed slurry. |
| Microbial Limits | Membrane Filtration and Culture | Enumeration of aerobic microorganisms and absence testing for specified pathogens using nutrient media and incubation per pharmacopeial guidelines. |
Technical Specifications of 7-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 215–219 °C |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 7-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 7-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE
Safety Information of 7-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 7-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE
Industrial 7-BROMO-1,2,3,4-TETRAHYDROISOQUINOLINE HYDROCHLORIDE Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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