(2S)-tert-Butyl 3-cyano-2-methyl-4-oxopiperidine-1-carboxylate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 2212021-56-0 |
| Product name | (2S)-tert-Butyl 3-cyano-2-methyl-4-oxopiperidine-1-carboxylate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 2212021-56-0
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2212021-56-0 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2212021-56-0
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Industry | Serves as a key chiral building block and intermediate for the synthesis of active pharmaceutical ingredients (APIs). | Used in nucleophilic substitution, reduction, hydrolysis, or cyclization reactions—leveraging the stereochemistry (2S) of its piperidine ring and reactive functional groups (cyano, carbonyl, and Boc-protected amine)—to construct the core scaffold of drug molecules. |
| Pharmaceutical Industry | Synthetic intermediate for specific protease inhibitors (e.g., dipeptidyl peptidase-4 [DPP-4] inhibitors). | Serves as a starting material for synthesizing non-amino acid-based protease inhibitor structures (e.g., cyanopyrrolidines or piperidinone derivatives), with structural modifications enhancing selectivity and metabolic stability. |
| CRO/CDMO | Compound library construction in new drug discovery. | Applied in diversity-oriented synthesis (DOS) to rapidly generate large numbers of derivatives for high-throughput screening—capitalizing on its multiple stereocenters and reactive sites. |
Manufacturing Quality Control of 2212021-56-0
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at 210-230 nm based on peak area calibration against reference standard. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities using gradient HPLC with UV detection and relative response factors. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., toluene, THF, ethyl acetate) by gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Determines trace water via coulometric or volumetric titration using iodine generation in pyridine-free reagents. |
| Heavy Metals | ICP-MS | Quantifies elemental impurities (e.g., Pb, Cd, Ni, Pd) by inductively coupled plasma mass spectrometry after acid digestion. |
| Chloride Content | Ion Chromatography | Separates and quantifies chloride ions using suppressed conductivity detection after aqueous extraction. |
| Residual Palladium | ICP-MS | Specific quantification of palladium from catalytic residues using isotope-dilution ICP-MS following microwave digestion. |
| Optical Rotation | [alpha]D Measurement | Measures specific rotation using sodium D-line light to confirm chiral integrity and enantiomeric excess. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid transition using calibrated capillary method per USP <741>. |
| Particle Size Distribution | Laser Diffraction | Analyzes dry or wet dispersed sample to report D10, D50, D90 values based on Mie scattering theory. |
| Loss on Drying | Gravimetric Thermogravimetry | Measures mass loss after heating at 105 C for 2 hours under controlled humidity and airflow. |
| Microbial Limits | Membrane Filtration + Culture | Detects aerobic microorganisms and specified pathogens using filtration, incubation on selective media, and colony enumeration. |
Technical Specifications of 2212021-56-0
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.0% |
| Single Impurity | <=0.3% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128°C to 132°C |
| Optical Rotation | +22.5° to +24.5° (c=1, in CHCl3) |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 2212021-56-0
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2212021-56-0
Packaging of 2212021-56-0
Industrial 2212021-56-0 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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