4-Fluoro-alpha-methyl-benzenepropanic acid Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 22138-73-4 |
| Product name | 4-Fluoro-alpha-methyl-benzenepropanic acid |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4-Fluoro-alpha-methyl-benzenepropanic acid
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4-Fluoro-alpha-methyl-benzenepropanic acid Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4-Fluoro-alpha-methyl-benzenepropanic acid
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral synthetic intermediate for the preparation of antidepressants and neuroactive compounds | Synthesis of chiral intermediates via asymmetric hydrogenation or enzymatic resolution, followed by condensation or esterification |
| Pharmaceutical R&D | Building block for drug molecules containing fluorinated phenylalanine derivatives | Used as a precursor in nucleophilic substitution or coupling reactions to introduce the fluoromethylphenylacetic acid moiety |
| Chemical Synthesis | Organic building block for the preparation of fluorinated amino acid analogs | Prepared through multi-step synthesis involving aromatic fluorination, side-chain oxidation, and stereoselective alkylation |
Manufacturing Quality Control of 4-Fluoro-alpha-methyl-benzenepropanic acid
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reverse-phase HPLC with UV detection at ~220 nm, comparing peak area against a certified reference standard. |
| Related Substances | HPLC-UV or UPLC-MS | Separation and detection of impurities (e.g., unreacted precursors, isomers, dehalogenated by-products) using gradient HPLC/UV or mass-selective detection. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify volatile organic solvents (e.g., toluene, THF, methanol) per ICH Q3C guidelines. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration quantifying water via iodine generation and stoichiometric reaction with sample moisture. |
| Heavy Metals | ICP-MS | Multi-element quantification of toxic metals (e.g., Pb, Cd, Hg, As) after acid digestion, achieving sub-pptr detection limits. |
| Optical Rotation | [α]D Measurement | Polarimetric determination of specific rotation at 589 nm to confirm chiral integrity and enantiomeric excess. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition measurement using standardized capillary method (e.g., USP <741>) to verify crystalline identity and purity. |
| Residue on Ignition | Gravimetric Analysis | High-temperature ashing followed by weighing of inorganic residue to assess non-volatile inorganic impurities. |
| Chloride Impurity | Ion Chromatography (IC) | Separation and conductivity detection of chloride ions after aqueous extraction and filtration. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry or wet dispersed sample to determine D10/D50/D90 values per ISO 13320. |
| pH of Aqueous Suspension | pH Meter | Measurement of pH in a defined saturated aqueous suspension (e.g., 1% w/v) to assess acidic functionality and potential hydrolysis. |
| Bulk and Tapped Density | ASTM D6393 | Gravimetric determination of powder density using standardized tapping apparatus to evaluate flow and compaction behavior. |
| Microbial Limits | Membrane Filtration & Culture | Enumeration of aerobic microorganisms and detection of specified pathogens per USP <61> and <62>. |
Technical Specifications of 4-Fluoro-alpha-methyl-benzenepropanic acid
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Melting Point | 102.0–106.0°C |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
| Optical Rotation | +15.0° to +19.0° (c=1, in methanol) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4-Fluoro-alpha-methyl-benzenepropanic acid
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4-Fluoro-alpha-methyl-benzenepropanic acid
Safety Information of 4-Fluoro-alpha-methyl-benzenepropanic acid
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 4-Fluoro-alpha-methyl-benzenepropanic acid
Industrial 4-Fluoro-alpha-methyl-benzenepropanic acid Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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