3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE-2-CARBOXYLIC ACID ETHYL ESTER Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 22244-22-0 |
| Product name | 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE-2-CARBOXYLIC ACID ETHYL ESTER |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 22244-22-0
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 22244-22-0 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 22244-22-0
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Used in the synthesis of benzoxazine compounds as precursors to active pharmaceutical ingredients | Prepared via organic synthesis steps including ester hydrolysis, cyclization, or functional group transformations |
| Organic Synthesis | Serves as a building block for constructing heterocyclic structures and participates in multistep synthetic reactions | Undergoes nucleophilic substitution, reduction, or condensation reactions under acidic or basic conditions |
| Drug Discovery | Employed in screening and developing small-molecule drug candidates with potential biological activity | High-throughput synthesis and structural modification, coupled with in vitro activity testing to optimize molecular structure |
Manufacturing Quality Control of 22244-22-0
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at 210-230 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Separation and quantification of impurities using gradient HPLC-UV; identification based on retention time matching and threshold limits per ICH Q3B. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify residual ethyl acetate, ethanol, and other process solvents against calibrated standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine trace water content via stoichiometric reaction. |
| Heavy Metals | ICP-MS | Multi-element quantification of Pb, Cd, Hg, As, and others after acid digestion, using isotopic detection with high sensitivity and low detection limits. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride ions using suppressed conductivity detection after aqueous extraction. |
| Sulfated Ash | Gravimetric Analysis | Ignition at 700-800 C followed by weighing of inorganic residue after treatment with sulfuric acid. |
| Optical Rotation | [a]D Measurement | Determination of specific optical rotation using sodium D-line light source to assess chiral integrity and enantiomeric purity. |
| Melting Point | Capillary Melting Point Apparatus | Thermal analysis by controlled heating to observe solid-to-liquid transition range, indicating crystallinity and purity. |
| Appearance | Visual Inspection | Assessment of physical state, color, and presence of visible particulates or discoloration under standardized lighting conditions. |
| pH of Aqueous Suspension | pH Meter | Measurement of pH in a defined suspension (e.g., 1% w/v in water) using calibrated electrode to evaluate acidic/basic impurities. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder size distribution by measuring angular scattering intensity of laser light through dispersed sample. |
Technical Specifications of 22244-22-0
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 85–89°C |
| Residue on Ignition | <=0.3% |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 22244-22-0
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 22244-22-0
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Industrial 22244-22-0 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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