3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 22246-18-0 |
| Product name | 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Intermediate in the synthesis of laquinimod | Used in chemical synthesis |
| Pharmaceuticals | Intermediate in the synthesis of roluquinimod | Used in chemical synthesis |
| Pharmaceuticals | Active pharmaceutical ingredient (API) precursor for research into drugs targeting autoimmune diseases (e.g., multiple sclerosis) | Used in chemical synthesis |
Manufacturing Quality Control of 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Identification | Infrared Spectroscopy (IR) | Determine the infrared absorption spectrum of the sample and compare it with standard spectra to confirm the presence of characteristic functional groups (such as hydroxyl, carbonyl, aromatic rings, etc.), used for compound structure identification. |
| Identification | Proton Nuclear Magnetic Resonance (¹H NMR) | Use nuclear magnetic resonance technology to determine the chemical shifts, coupling constants, and integral areas of hydrogen atoms in the sample. Compare with standard spectra to verify the structural features of the target compound. |
| Identification | Mass Spectrometry (MS) | Ionize the sample to produce molecular ion peaks and fragment ion peaks, measure their mass-to-charge ratio (m/z), confirm the molecular weight and structural information, and assist in structural confirmation. |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Use a reverse-phase C18 chromatographic column, with methanol-water or acetonitrile-water as the mobile phase, and a UV detector (usually at 254 nm or maximum absorption wavelength) for detection. Determine the content of the main component using external standard or internal standard methods. |
| Related Substances (Impurities) Test | High-Performance Liquid Chromatography (HPLC) | Use similar chromatographic conditions to those used in content determination but optimize the gradient elution program to achieve good separation between the main peak and potential impurities. Control impurity limits using area normalization or the main component self-reference method with correction factors. |
| Dry Loss | Thermogravimetric Analysis (TGA) or Constant-Temperature Drying Method | Dry the sample at a specified temperature (e.g., 105°C) until constant weight is achieved, and measure the percentage of mass loss to evaluate the content of moisture and volatile substances. |
| Residual Carbonized Material | High-Temperature Incineration Method | Carbonize the sample and then incinerate it in a high-temperature furnace at 700–800°C. Weigh the residual inorganic material to control the total amount of inorganic impurities. |
| Residual Solvents | Gas Chromatography (GC) | Use headspace sampling or direct injection with an FID detector. Quantitatively detect organic solvents potentially remaining from the synthesis process (e.g., methanol, ethanol, dichloromethane, etc.) according to the Chinese Pharmacopoeia or ICH guidelines. |
| Melting Point | Capillary Melting Point Determination | Load the sample into a capillary tube and gradually heat it in a melting point apparatus. Observe the temperature range from initial melting to complete melting, which serves as an auxiliary indicator for purity and identity verification. |
| pH Value (if in solution) | pH Meter Measurement | Prepare a solution of a certain concentration of the test sample and use a calibrated pH meter to measure its acidity or alkalinity, assessing whether its physicochemical properties meet the requirements. |
Technical Specifications of 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
| Test Item | Specification |
|---|---|
| Appearance | White to light yellow crystalline powder |
| Purity | >=98.0% (HPLC) |
| Melting Point | 178–182°C |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
Safety Information of 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone
Industrial 3,4-Dihydro-7-hydroxy-2(1H)-quinolinone Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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