4,4-Difluorocyclohexanol Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 22419-35-8 |
| Product name | 4,4-Difluorocyclohexanol |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradePharmaceutical GradeElectronic GradeMaterial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 4,4-Difluorocyclohexanol
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 4,4-Difluorocyclohexanol Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 4,4-Difluorocyclohexanol
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key chiral intermediate for synthesizing fluorinated pharmaceuticals, including antifungals, antivirals, and central nervous system agents | Produced via chiral resolution or asymmetric catalytic reduction of 4,4-difluorocyclohexanone; subsequently used to construct fluorinated cyclohexyl structural units |
| Agrochemical Intermediates | Preparation of novel fluorinated insecticides and fungicides to enhance lipophilicity and metabolic stability | Introduced as a fluorinated cyclohexanol scaffold into active molecules, followed by derivatization via halogenation, sulfonylation, or coupling reactions |
| Liquid Crystal Materials | Synthesis of high-performance liquid crystal monomers to improve dielectric anisotropy and clearing point | Linked to aromatic rings (e.g., biphenyl, pyrimidine) via ether or ester bonds to form fluorinated flexible spacer structures |
| Organic Synthesis Reagents | Fluorinated building block for cross-coupling reactions, including Heck and Suzuki couplings | Activated (e.g., converted to triflate) for palladium-catalyzed C–O or C–C bond formation |
Manufacturing Quality Control of 4,4-Difluorocyclohexanol
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | Gas Chromatography (GC) with FID detector | Quantitative determination based on peak area comparison against a certified reference standard under validated chromatographic conditions. |
| Water Content | Karl Fischer Titration | Electrochemical titration where iodine reacts stoichiometrically with water in a methanol-based reagent; endpoint detected amperometrically. |
| Residue on Ignition | Gravimetric Analysis | Sample is ignited at 700-800 C to volatilize organic matter; inorganic residue is weighed after cooling in a desiccator. |
| Acidity (as HCl) | Acid-Base Titration with NaOH | Neutralization of acidic impurities using standardized sodium hydroxide solution with phenolphthalein indicator. |
| Heavy Metals | ICP-OES | Multi-element detection by measuring atomic emission intensities of metals in plasma after acid digestion of the sample. |
| Chloride Impurity | Ion Chromatography (IC) | Separation and quantification of chloride anions using suppressed conductivity detection after ion exchange separation. |
| Residual Solvents | Gas Chromatography (GC) with Headspace Sampling | Volatile solvents are equilibrated in headspace vial, injected into GC, and quantified against calibration standards. |
| Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light passing through a solution, indicating chiral purity and enantiomeric excess. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity against established specifications using white background and controlled lighting. |
| Boiling Point | Distillation Method (ASTM D1078) | Determination of temperature range at which vapor pressure equals atmospheric pressure during controlled micro-distillation. |
| Refractive Index | Refractometry | Measurement of light bending angle at air-sample interface using calibrated Abbe refractometer at specified temperature. |
| Specific Gravity | Pycnometry | Density determination by comparing mass of known volume of sample to mass of same volume of water at 20 C. |
Technical Specifications of 4,4-Difluorocyclohexanol
| Test Item | Specification |
|---|---|
| Appearance | Colorless solid |
| Purity | >=98.0% (GC-MS) |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 48–52°C |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 4,4-Difluorocyclohexanol
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 4,4-Difluorocyclohexanol
Packaging of 4,4-Difluorocyclohexanol
Industrial 4,4-Difluorocyclohexanol Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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