N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 231278-20-9 |
| Product name | N-[3-Chloro-4-(3-fluorobenzyloxy)phenyl]-6-iodoquinazolin-4-amine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 231278-20-9
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 231278-20-9 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 231278-20-9
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Experimental anticancer drug candidate targeting epidermal growth factor receptor (EGFR) mutants and HER2 kinase | Used as a small-molecule tyrosine kinase inhibitor for pharmacodynamic evaluation in vitro (cell proliferation inhibition assays) and in vivo (mouse xenograft models); synthesized via multi-step solid-phase or solution-phase synthesis, with key steps including quinazoline ring formation, halogen exchange, and aryl etherification |
Manufacturing Quality Control of 231278-20-9
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies main component using reversed-phase HPLC with UV detection at characteristic wavelength, comparing peak area to reference standard calibration curve. |
| Related Substances | HPLC-UV | Detects and quantifies structurally related impurities by separation on C18 column with gradient elution and UV detection. |
| Residual Solvents | GC-FID | Identifies and quantifies volatile organic solvents using gas chromatography with flame ionization detection against certified standards. |
| Water Content | Karl Fischer Titration | Determines trace water by coulometric or volumetric titration based on iodine consumption in pyridine-methanol buffer. |
| Heavy Metals | ICP-MS | Measures total elemental impurities (e.g., Pb, Cd, Ni, As) via inductively coupled plasma mass spectrometry after acid digestion. |
| Chloride Impurity | Ion Chromatography | Separates and quantifies chloride ions using anion-exchange column with conductivity detection. |
| Iodine Content | Oxidimetric Titration (with Na2S2O3) | Determines total iodine after alkaline fusion and oxidation to iodate, followed by iodometric back-titration. |
| Residue on Ignition | Gravimetric Analysis | Measures non-volatile inorganic residue after high-temperature ashing at 600-750 C and weighing. |
| Particle Size Distribution | Laser Diffraction | Analyzes dry or wet dispersed sample using light scattering pattern to calculate size distribution by Mie theory. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range of solid-to-liquid phase transition using calibrated capillary tube method per USP <741>. |
| Specific Optical Rotation | Polarimetry | Measures angle of rotation of plane-polarized light caused by chiral centers in solution at specified concentration and wavelength. |
| Microbial Limits | Membrane Filtration | Quantifies aerobic microorganisms and detects specified pathogens (e.g., E. coli, S. aureus) using selective agar media and incubation. |
Technical Specifications of 231278-20-9
| Test Item | Specification |
|---|---|
| Appearance | Yellow solid |
| Purity | >=99.0% (LC-MS) |
| Total Impurities | <=1.0% |
| Single Impurity | <=0.5% |
| Melting Point | 218–222°C |
| Water Content (KF) | <=0.5% |
| Identification (NMR) | Conforms to reference spectrum |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 231278-20-9
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 231278-20-9
Packaging of 231278-20-9
Industrial 231278-20-9 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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