L-Propargylglycine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 23235-01-0 |
| Product name | L-Propargylglycine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for L-Propargylglycine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk L-Propargylglycine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of L-Propargylglycine
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical R&D | Used as an amino acid analog to inhibit cysteine proteases (e.g., cathepsin B) in mechanistic studies of cancer, inflammation, and neurodegenerative diseases | Synthesized via nucleophilic substitution of L-serine with propargyl bromide under basic conditions, followed by purification to obtain high-purity L-propargylglycine |
| Biochemistry | Applied in enzymology studies as an irreversible inhibitor probe to characterize active sites of cysteine-containing enzymes | Incorporated into peptide chains as a non-canonical amino acid via solid-phase peptide synthesis (SPPS) or solution-phase synthesis |
| Medicinal Chemistry | Employed as a structural building block in prodrugs or drug molecules for designing antiviral or anticancer compounds targeting cysteine proteases | Conjugated to drug scaffolds (e.g., peptides or small-molecule inhibitors) via coupling reactions to generate covalent lead compounds |
Manufacturing Quality Control of L-Propargylglycine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at 200-220 nm, comparing peak area against a certified reference standard. |
| Chiral Purity | Chiral HPLC | Enantiomeric excess assessment using a chiral stationary phase and UV detection, resolving L- and D-enantiomers. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration with iodine-based reagent to quantify water via stoichiometric reaction. |
| Residue on Ignition | Gravimetric Analysis | Heating sample to 700-800 C in a platinum crucible and measuring non-volatile inorganic residue by weight difference. |
| Heavy Metals | ICP-OES | Multi-element quantification of Pb, Cd, Hg, As, and other regulated metals after acid digestion and plasma emission spectroscopy. |
| Chloride Impurity | Ion Chromatography | Separation and quantification of chloride anion using suppressed conductivity detection after aqueous extraction. |
| Sulfate Impurity | Ion Chromatography | Separation and quantification of sulfate anion using suppressed conductivity detection after aqueous extraction. |
| Related Substances | HPLC-UV | Detection and quantification of structurally similar impurities (e.g., glycine, propargylamine, N-oxide) using gradient HPLC-UV. |
| Specific Optical Rotation | Polarimetry | Measurement of optical rotation at 20 C using sodium D-line (589 nm) to confirm chiral integrity and concentration. |
| pH (1% w/v aqueous solution) | Potentiometric pH Measurement | Determination of hydrogen ion activity in aqueous solution using calibrated glass electrode and pH meter. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder size distribution by measuring angular variation in laser light scattering. |
| Microbial Contamination | Membrane Filtration | Quantitative recovery and enumeration of aerobic microorganisms from dissolved sample via filtration and agar culture. |
Technical Specifications of L-Propargylglycine
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -35.0 to -31.0 deg (c=1, H2O) |
| Melting Point | 178 to 182 °C |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of L-Propargylglycine
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of L-Propargylglycine
Packaging of L-Propargylglycine
Industrial L-Propargylglycine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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