2-Chloro-4-amino-6,7-dimethoxyquinazoline Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 23680-84-4 |
| Product name | 2-Chloro-4-amino-6,7-dimethoxyquinazoline |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for 2-Chloro-4-amino-6,7-dimethoxyquinazoline
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 2-Chloro-4-amino-6,7-dimethoxyquinazoline Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 2-Chloro-4-amino-6,7-dimethoxyquinazoline
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate in the synthesis of α1-adrenergic receptor antagonists (e.g., doxazosin) | Used as an electrophile in nucleophilic substitution reactions with amines to construct the core drug structure |
| Materials Science | Synthesis of organic functional molecules or liquid crystal materials | Serves as a building block for quinazoline derivatives, enabling preparation of target materials via subsequent functionalization |
| R&D | Chemical reference standard for analytical method development and validation | Used for instrument calibration (e.g., HPLC, LC-MS) and method development |
| R&D | Synthesis of other complex quinazoline compounds for biological activity screening | Serves as a versatile synthon for preparing compound libraries via alkylation, acylation, and related reactions |
Manufacturing Quality Control of 2-Chloro-4-amino-6,7-dimethoxyquinazoline
| Test Item | Common Testing Method | Method Overview |
|---|---|---|
| Appearance | Visual Inspection | Observe the color, physical state, and presence of visible foreign matter under natural light or standard illumination. |
| Identification | Infrared Spectroscopy (IR) | Compare the sample spectrum with a reference standard; confirm molecular structure based on characteristic absorption peaks (e.g., N-H, C=O, C-Cl, aromatic rings). |
| Proton Nuclear Magnetic Resonance (¹H-NMR) | Analyze chemical shifts, coupling constants, and integration areas of hydrogen atoms to verify the hydrogen distribution in the molecular structure. | |
| Assay | High-Performance Liquid Chromatography (HPLC) | Use a reversed-phase C18 column and UV detector (typically at 254 nm or 280 nm) to quantify the main component via external or internal standard method. |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Separate impurities using gradient or isocratic elution, detect and quantify individual impurity peaks to assess purity and impurity limits. |
| Water Content | Karl Fischer Titration | Determine water content based on the quantitative reaction of iodine and sulfur dioxide with water in the presence of pyridine and methanol. |
| Loss on Drying | Thermogravimetric Analysis (TGA) or Oven Method | Dry the sample at a specified temperature (e.g., 105°C) to constant weight; calculate total volatile content based on weight loss. |
| Sulfated Ash | Sulfated Residue Method | Char the sample, treat with sulfuric acid, then ignite at high temperature; weigh the residual inorganic matter to evaluate inorganic impurity levels. |
| Heavy Metals | Atomic Absorption Spectroscopy (AAS) or ICP-MS | Digest the sample and measure concentrations of heavy metal elements (e.g., lead, cadmium, mercury, arsenic) to ensure compliance with pharmacopoeial limits. |
| Residual Solvents | Gas Chromatography (GC) | Detect organic solvents potentially remaining from manufacturing (e.g., methanol, ethanol, dichloromethane, DMF) according to ICH guidelines. |
| Melting Point | Capillary Melting Point Method | Determine the temperature range from initial melting to complete melting using a melting point apparatus; used for preliminary assessment of purity and identity. |
| Crystal Form Analysis | X-Ray Powder Diffraction (XRPD) | Analyze characteristic diffraction peaks to identify crystal structure, detect polymorphic forms, or non-crystalline impurities. |
| Particle Size Distribution | Laser Diffraction Analysis (LDA) | Measure particle size and distribution based on laser light scattering; suitable for controlling physical properties of raw materials prior to formulation. |
Technical Specifications of 2-Chloro-4-amino-6,7-dimethoxyquinazoline
| Test Item | Specification |
|---|---|
| Appearance | Off-white crystalline solid |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 198–202°C |
| Identification (NMR) | Consistent with structure |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of 2-Chloro-4-amino-6,7-dimethoxyquinazoline
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of 2-Chloro-4-amino-6,7-dimethoxyquinazoline
Safety Information of 2-Chloro-4-amino-6,7-dimethoxyquinazoline
| Pictograms |   |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of 2-Chloro-4-amino-6,7-dimethoxyquinazoline
Industrial 2-Chloro-4-amino-6,7-dimethoxyquinazoline Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply