5-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 239463-85-5 |
| Product name | 5-[(2R)-2-Aminopropyl]-1-[3-(benzoyloxy)propyl]-2,3-dihydro-1H-indole-7-carbonitrile (2R,3R)-2,3-dihydroxybutanedioate |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 239463-85-5
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 239463-85-5 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 239463-85-5
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Used as a selective 5-HT1B/1D receptor agonist for migraine treatment | Administered orally to act on intracranial blood vessels and the trigeminal nerve pathway, inducing vasoconstriction and inhibiting neuropeptide release |
| Pharmaceutical R&D | Employed as a candidate drug or lead compound in the development of novel anti-migraine agents | Subjected to pharmacodynamic, pharmacokinetic, and safety evaluations during preclinical and clinical studies |
| Chemical Synthesis | Utilized as an intermediate for synthesizing structural analogs to optimize pharmacological activity | Structurally modified via organic synthesis methods including functional group modification, salt form screening, and chiral resolution |
Manufacturing Quality Control of 239463-85-5
| Test Item | Common Testing Methods | Method Overview |
|---|---|---|
| Identification | Infrared Spectroscopy (IR) | Compares sample spectrum with reference spectra to confirm consistency of molecular functional groups and structural features. |
| Nuclear Magnetic Resonance Spectroscopy (NMR, ¹H/¹³C) | Analyzes chemical environments via proton and carbon NMR to confirm molecular structure and stereochemistry (e.g., R configuration). | |
| Mass Spectrometry (MS or HRMS) | Determines molecular ion peak to verify molecular weight and fragmentation pattern, confirming molecular formula. | |
| Content Determination | High-Performance Liquid Chromatography (HPLC) | Uses C18 column with UV detector (e.g., 254 nm), gradient or isocratic elution; quantifies main component by external or internal standard method. |
| Non-aqueous Titration | Titrates the basic amino group in tartrate salt using standardized perchloric acid in non-aqueous solvent (e.g., glacial acetic acid) to determine free base content. | |
| Related Substances (Impurities) | High-Performance Liquid Chromatography (HPLC) | Applies gradient elution to detect degradation products, synthetic intermediates, or stereoisomeric impurities; calculates individual impurity peak areas and reports results. |
| Water Content | Karl Fischer Titration | Accurately measures combined and free water content, suitable for hygroscopic substances such as tartrate salts. |
| Residual Solvents | Gas Chromatography (GC) | Uses headspace injection to detect residual organic solvents (e.g., methanol, ethanol, acetone, dichloromethane) from manufacturing processes. |
| Polymorphic Analysis | X-Ray Powder Diffraction (XRD) | Analyses characteristic diffraction peaks of solid-state crystal forms to confirm crystalline form consistency, essential for polymorph control. |
| Melting Point | Capillary Melting Point Method | Determines the temperature range from solid to liquid state, used for preliminary identification and purity assessment. |
| Specific Rotation | Polarimeter Measurement | Measures optical rotation at a specified wavelength to verify optical purity, particularly focusing on the chiral center with (2R) configuration. |
| Solution Clarity and Color | Visual Comparison Method | Dissolves sample in specified solvent and compares clarity and color with standard reference solutions to assess compliance. |
| Loss on Drying | Thermogravimetric Analysis (TGA) or Oven Method | Measures mass loss after heating under defined conditions to evaluate volatile components or solvent residues. |
| Residue on Ignition | Sulfated Ash Method | After high-temperature incineration followed by sulfuric acid charring, determines the amount of inorganic impurities remaining. |
| Particle Size Distribution | Laser Diffraction Analysis (LDA) | Measures particle size distribution based on laser scattering principles; impacts dissolution behavior and formulation performance. |
Technical Specifications of 239463-85-5
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 178–182°C |
| Optical Rotation | +12.0 to +14.0° (c=1, in methanol) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of 239463-85-5
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
Packaging of 239463-85-5
Industrial 239463-85-5 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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