L-Valine benzyl ester hydrochloride Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 2462-34-2 |
| Product name | L-Valine benzyl ester hydrochloride |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for L-Valine benzyl ester hydrochloride
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk L-Valine benzyl ester hydrochloride Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of L-Valine benzyl ester hydrochloride
| Industry | Application | Process |
|---|---|---|
| Pharmaceutical Intermediates | Key chiral intermediate for synthesizing antihypertensive drugs (e.g., Valsartan) | Deprotection under basic conditions and coupling in organic solvents to construct peptide-based pharmaceuticals |
| Pharmaceutical Intermediates | Protected form of L-valine, used in amino acid coupling reactions during solid-phase peptide synthesis | Used as an N-terminally protected amino acid monomer in solid-phase peptide synthesis (SPPS); coupled to resin-bound peptide chains after activation with DIC/HOBt |
| Pharmaceutical Intermediates | Precursor for preparing other valine derivatives (e.g., L-valine methyl ester, L-valine tert-butyl ester) | Selective benzyl group removal via catalytic hydrogenolysis (Pd/C, H₂) or acidic cleavage (HBr/AcOH), followed by ester exchange or salt formation to yield target derivatives |
Manufacturing Quality Control of L-Valine benzyl ester hydrochloride
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantification using reversed-phase HPLC with UV detection at 210 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV | Separation and detection of structurally related impurities using gradient HPLC-UV; identification and quantification against reference standards or threshold limits. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify residual solvents (e.g., methanol, ethyl acetate, toluene) based on calibrated external standards. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration using iodine-based reagent to determine water content via stoichiometric reaction with water. |
| Optical Rotation | [alpha]D Measurement | Measurement of specific optical rotation using a polarimeter at 20 C and sodium D-line (589 nm) to confirm chiral integrity and enantiomeric purity. |
| Heavy Metals | ICP-OES | Multi-element quantification of Pb, Cd, Hg, As, and other regulated metals after acid digestion, using inductively coupled plasma optical emission spectrometry. |
| Chloride Content | Potentiometric Titration | Titration with silver nitrate using a silver indicator electrode to determine chloride ion concentration based on precipitation endpoint. |
| Residue on Ignition | Gravimetric Analysis | Weighing residue remaining after high-temperature ashing (600-700 C) to assess inorganic non-volatile impurities. |
| pH (1% aqueous solution) | pH Meter Measurement | Direct measurement of pH in a 1% w/v aqueous solution using a calibrated pH meter with glass electrode. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity against established reference standards under controlled lighting conditions. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, using calibrated capillary apparatus per pharmacopeial methods. |
| Microbial Limits | Membrane Filtration and Culture | Enumeration of aerobic microorganisms and absence testing for specified pathogens using membrane filtration followed by incubation on selective media. |
Technical Specifications of L-Valine benzyl ester hydrochloride
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 148-152°C |
| Optical Rotation | -9.0 to -11.0° (c=1, in 6N HCl) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Heavy Metals | <=20 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of L-Valine benzyl ester hydrochloride
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of L-Valine benzyl ester hydrochloride
Safety Information of L-Valine benzyl ester hydrochloride
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of L-Valine benzyl ester hydrochloride
Industrial L-Valine benzyl ester hydrochloride Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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