China Factory Direct
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| CAS number | 251570-03-3 |
| Product name | (4-CHLORO-3-FLUORO-PHENYL)-ACETONITRILE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pesticides | Intermediate for synthesizing fluorinated chlorobenzyl acetonitrile-based herbicides and insecticides | Produced via nucleophilic substitution of 3-fluoro-4-chlorobromobenzene with sodium cyanide in a polar solvent |
| Pharmaceuticals | Aromatic nitrile intermediate for synthesizing antidepressants, antitumor agents, or protease inhibitors | Generated by transition-metal-catalyzed or direct cyanation of corresponding haloarenes with a cyanide source |
| Dyes & Pigments | Precursor for synthesizing specialty fluorescent dyes or high-stability organic pigments | Functionalized via further transformations of the nitrile group—such as hydrolysis, reduction, or coupling reactions—to construct the chromophore system |
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | GC-FID or GC-MS | Quantitative determination by comparing peak area of analyte to calibration standard using gas chromatography with flame ionization or mass spectrometric detection. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration based on the stoichiometric reaction of water with iodine and sulfur dioxide in a pyridine-methanol medium. |
| Residual Solvents | GC-FID | Identification and quantification of volatile organic solvents by retention time matching and peak area comparison against reference standards. |
| Heavy Metals | ICP-OES | Multi-element detection via measurement of atomic emission intensities from plasma-excited atoms in solution after acid digestion. |
| Chloride Impurities | Ion Chromatography (IC) | Separation and quantification of chloride ions using anion-exchange column and conductivity detection. |
| Fluoride Impurities | Ion-Selective Electrode (ISE) | Potentiometric measurement of fluoride ion activity in solution using a lanthanum fluoride crystal membrane electrode. |
| Related Substances | HPLC-UV | Separation and quantification of structurally related impurities using reversed-phase chromatography and UV absorbance detection. |
| Melting Point | Capillary Melting Point Apparatus | Determination of temperature range at which solid transitions to liquid, indicating purity and identity. |
| Appearance | Visual Inspection | Assessment of physical state, color, and clarity against established reference standards under controlled lighting. |
| Acid Value | Acid-Base Titration | Quantification of acidic impurities by titration with standardized sodium hydroxide solution using phenolphthalein indicator. |
| Residue on Ignition | Gravimetric Analysis | Measurement of non-volatile inorganic residue after high-temperature ashing of sample in a platinum crucible. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light caused by chiral compounds in solution. |
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline solid |
| Purity | >=98.0% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 68.0–72.0°C |
| Identification (NMR) | Consistent with structure |
| Identification (IR) | Consistent with structure |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
| Pictograms | ![]() |
| Signal Word | Warning |
| Safety Data Sheet | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.