CHIR-99021 Bulk Supply for Industrial Use
China Factory Direct
 |
|
| CAS number | 252917-06-9 |
| Product name | CHIR-99021 |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag500KG/bag1000KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
QUOTE TYPE
PACKAGING TYPE
TOTAL QUANTITY(KG)
PREFERRED SHIPPING METHOD
YOUR COMPANY
YOUR E-MAIL
Calculate Summary
Based on current marketvolatility and material availability.
Documents We Provide for CHIR-99021
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk CHIR-99021 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of CHIR-99021
| Industry | Application | Process |
|---|---|---|
| Biopharmaceutical R&D | Used to inhibit glycogen synthase kinase-3β (GSK-3β) for studying the impact of the Wnt/β-catenin signaling pathway on cell fate regulation | Cell culture (typically added as a supplement at concentrations ranging from 3–10 μM) |
| Biopharmaceutical R&D | Induces and maintains pluripotent stem cells, enhancing reprogramming efficiency | Used in combination with factors such as meisoindigo, PD0325901, or SB431542 (e.g., in 2i/L culture systems) |
| Biopharmaceutical R&D | Supports directed differentiation studies of stem cells into specific lineages, including neural progenitor cells and cardiomyocytes | In vitro differentiation culture of embryonic stem cells or induced pluripotent stem cells |
| Pharmaceutical R&D | Screening and validation of potential drug targets associated with GSK-3β activity in diseases such as Alzheimer’s disease, diabetes, and cancer | Enzyme activity inhibition assays (biochemical analysis) and cellular pharmacological evaluation |
| Regenerative Medicine | Investigates tissue regeneration mechanisms by activating the Wnt signaling pathway to promote tissue repair and regeneration | Studies in relevant animal models or in vitro organoid construction |
Manufacturing Quality Control of CHIR-99021
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantifies CHIR-99021 concentration using reverse-phase HPLC with UV detection at ~280 nm, comparing peak area to a certified reference standard. |
| Related Substances | HPLC-UV/DAD or UPLC-MS | Separates and detects structurally related impurities (e.g., synthesis intermediates, degradants) via retention time and spectral matching. |
| Residual Solvents | GC-FID | Measures volatile organic solvents (e.g., methanol, acetone, DMF) by gas chromatography with flame ionization detection against calibrated standards. |
| Heavy Metals | ICP-MS | Quantifies trace metal contaminants (e.g., Pd, Ni, Fe) using inductively coupled plasma mass spectrometry for sub-ppt sensitivity. |
| Water Content | Karl Fischer Titration | Determines water content via coulometric or volumetric titration based on the electrochemical reaction between iodine and water. |
| Optical Rotation | [α]D | Measures specific optical rotation using a polarimeter at 589 nm to confirm chiral integrity and enantiomeric identity. |
| Residue on Ignition | Gravimetric Analysis | Determines inorganic ash content by high-temperature incineration followed by precise weighing of residual non-volatile matter. |
| Particle Size Distribution | Laser Diffraction | Analyzes dry or wet dispersion particle size distribution using Mie scattering theory to assess crystallization and handling properties. |
| Microbial Limits | Membrane Filtration + Culture | Detects aerobic microorganisms and specified pathogens (e.g., E. coli, S. aureus) via filtration, incubation on selective media, and colony enumeration. |
| pH (in aqueous suspension) | Potentiometric pH Measurement | Measures hydrogen ion activity in a standardized aqueous suspension using a calibrated glass electrode and pH meter. |
| Melting Point | Capillary Melting Point Apparatus | Determines thermal transition range by observing solid-to-liquid phase change under controlled heating per pharmacopeial guidelines. |
| Chloride Impurity | Ion Chromatography (IC) | Quantifies chloride ions using suppressed conductivity detection after anion exchange separation. |
| Residual Palladium | ICP-OES | Measures palladium catalyst residue via inductively coupled plasma optical emission spectroscopy at characteristic emission wavelengths (e.g., 247.6 nm). |
Technical Specifications of CHIR-99021
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (HPLC) |
| Total Impurities | <=2.0% (HPLC) |
| Single Impurity | <=0.5% (HPLC) |
| Water Content (KF) | <=0.5% |
| Melting Point | 168–172°C |
| Identification (NMR) | Consistent with reference standard |
| Optical Rotation | -15.0 to -19.0° (c=1, in methanol) |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
|
|
Download COA of CHIR-99021
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of CHIR-99021
Packaging of CHIR-99021
Industrial CHIR-99021 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
Use Bulk
Supply Factory
Direct ISO 9001
Certified Samples
Available Stable
Supply