(R)-N-Boc-piperazine-2-carboxylic acid methyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 252990-05-9 |
| Product name | (R)-N-Boc-piperazine-2-carboxylic acid methyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical GradeIndustrial GradeSpecialty Grade |
| Packaging | 25L/drum |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for (R)-N-Boc-piperazine-2-carboxylic acid methyl ester
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk (R)-N-Boc-piperazine-2-carboxylic acid methyl ester Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of (R)-N-Boc-piperazine-2-carboxylic acid methyl ester
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Chiral intermediates for synthesizing piperazine-containing drug molecules (e.g., antidepressants, antipsychotics, antivirals) | Used as chiral building blocks in coupling, aminolysis, or reductive amination reactions; followed by Boc deprotection, hydrolysis, and condensation to construct target molecules |
| Pharmaceutical R&D | Starting material for synthesizing highly selective chiral ligands or catalysts | Employed to prepare chiral phosphoric ester ligands or metal-complex catalysts for asymmetric synthesis |
| Fine Chemicals | Structural unit for chiral functional materials | Incorporated into polymer backbones via polymerization or covalent modification for developing chiral separation media or sensors |
Manufacturing Quality Control of (R)-N-Boc-piperazine-2-carboxylic acid methyl ester
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reverse-phase HPLC with UV detection at ~210 nm, comparing peak area against a certified reference standard. |
| Chiral Purity (Enantiomeric Excess) | Chiral HPLC | Separation on a chiral stationary phase (e.g., Chiralpak AD-H) with UV detection; enantiomeric excess calculated from peak area ratio of (R)- and (S)-enantiomers. |
| Residual Solvents | GC-FID | Headspace GC with flame ionization detection to quantify common solvents (e.g., MeOH, THF, EtOAc) based on calibrated external standards. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration quantifying water via iodine generation and stoichiometric reaction with water in anhydrous methanol-based reagent. |
| Heavy Metals (Pb, Cd, Hg, As) | ICP-MS | Multi-element trace metal quantification after acid digestion, using isotopic detection with high sensitivity and low detection limits. |
| Residual Boc Reagent (Di-tert-butyl dicarbonate) | GC-MS | Detection and quantification of residual Boc₂O by gas chromatography coupled with mass spectrometric identification and calibration. |
| Related Substances | HPLC-UV (Forced Degradation Study) | Identification and quantification of process-related impurities and degradation products using gradient HPLC-UV under stressed conditions (acid/base/oxidative/thermal). |
| Optical Rotation | [α]D | Measurement of specific optical rotation at 589 nm (Na D-line) in solution (e.g., 1% w/v in CHCl₃), confirming chiral integrity and identity. |
| Residual Palladium (if Pd-catalyzed synthesis used) | ICP-OES | Quantification of palladium after microwave-assisted acid digestion using plasma emission at characteristic wavelengths (e.g., 340.458 nm). |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder particle size distribution using Mie scattering theory applied to laser diffraction patterns. |
| Melting Point | Automated Melting Point Apparatus | Determination of temperature range at which solid-to-liquid phase transition occurs, indicating crystallinity and purity. |
| pH of Aqueous Suspension | pH Meter | Measurement of pH in a standardized suspension (e.g., 10% w/v in water) to assess acidic/basic impurities or hydrolytic stability. |
| Loss on Drying (LOD) | Thermogravimetric Analysis (TGA) | Mass loss measured gravimetrically upon heating to 105°C under nitrogen, reflecting volatile content including solvates and moisture. |
| Microbial Limits | Membrane Filtration + Culture | Enumeration of aerobic microorganisms and detection of specified pathogens (e.g., E. coli, S. aureus) per pharmacopeial guidelines (USP <61>). |
Technical Specifications of (R)-N-Boc-piperazine-2-carboxylic acid methyl ester
| Test Item | Specification |
|---|---|
| Appearance | Colorless to pale yellow liquid |
| Purity | >=98.0% (GC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -15.0° to -19.0° (c=1, in CHCl3) |
| Identification (NMR) | Conforms to reference spectrum |
| Odor | Characteristic mild organic odor |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of (R)-N-Boc-piperazine-2-carboxylic acid methyl ester
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of (R)-N-Boc-piperazine-2-carboxylic acid methyl ester
Safety Information of (R)-N-Boc-piperazine-2-carboxylic acid methyl ester
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of (R)-N-Boc-piperazine-2-carboxylic acid methyl ester
Industrial (R)-N-Boc-piperazine-2-carboxylic acid methyl ester Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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