Sodium levothyroxine Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 25416-65-3 |
| Product name | Sodium levothyroxine |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Pharmaceutical Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for Sodium levothyroxine
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk Sodium levothyroxine Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of Sodium levothyroxine
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Treatment of hypothyroidism | Active pharmaceutical ingredient (API) in oral solid dosage forms (e.g., tablets), prepared via chemical synthesis or semi-synthesis, followed by tablet compression or capsule filling |
| Pharmaceuticals | Thyroid hormone suppression therapy following thyroid cancer surgery | Administered as high-dose L-thyroxine sodium tablets, manufactured using standard solid dosage form production processes |
| Pharmaceuticals | Thyroid function suppression testing for diagnostic purposes | Formulated into standardized-dose tablets for clinical functional assessment, produced via GMP-compliant API synthesis and formulation processes |
| Life Sciences Research | Hormonal supplementation in cell culture or animal studies | High-purity material dissolved and sterile-filtered prior to incorporation into culture media or formulation into injectable solutions for experimental use |
Manufacturing Quality Control of Sodium levothyroxine
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (L-Thyroxine Sodium Content) | HPLC-UV | Quantification by reversed-phase HPLC with UV detection at 225 nm, using a C18 column and aqueous acetonitrile mobile phase. |
| Related Substances | HPLC-UV | Separation and quantification of impurities (e.g., L-triiodothyronine, desiodo analogs) using gradient HPLC-UV under validated conditions. |
| Water Content | Karl Fischer Titration | Volumetric or coulometric titration with iodine-based reagent to determine trace water based on stoichiometric reaction. |
| Residue on Ignition | Gravimetric Analysis | Heating sample at 700-800 C to constant weight; residue mass reflects inorganic ash content. |
| Heavy Metals | ICP-OES | Multi-element quantification of Pb, Cd, Hg, As, and others after acid digestion, using plasma emission spectroscopy. |
| Sodium Content | Flame Photometry | Measurement of sodium-specific emission intensity at 589 nm in atomized aqueous solution. |
| pH (1% w/v solution) | Potentiometric pH Measurement | Determination using calibrated glass electrode in aqueous suspension at 25 C. |
| Specific Optical Rotation | Polarimetry | Measurement of rotation angle of plane-polarized light at 20 C using sodium D-line (589 nm). |
| Loss on Drying | Thermogravimetric Analysis | Weight loss measured after drying at 105 C for 2 hours under atmospheric pressure. |
| Microbial Limits | Membrane Filtration | Enumeration of aerobic mesophilic bacteria and detection of specified pathogens per USP <61> and <62>. |
| Particle Size Distribution | Laser Diffraction | Analysis of dry powder dispersion via light scattering to determine D10, D50, D90 values. |
| Sterility | Direct Inoculation | Aseptic transfer into thioglycolate and soybean-casein digest media, incubated for 14 days per USP <71>. |
Technical Specifications of Sodium levothyroxine
| Test Item | Specification |
|---|---|
| Appearance | Pale-yellow solid |
| Purity | >=98.0% (LC-MS) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | +13.5 to +16.5 deg (c=2, 1M HCl/EtOH 1:4) |
| Heavy Metals | <=20 ppm |
| Residue on Ignition | <=0.1% |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of Sodium levothyroxine
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NMR Spectra of Sodium levothyroxine
Packaging of Sodium levothyroxine
Industrial Sodium levothyroxine Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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