D-Glutamic acid 1-tert-butyl ester Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 25456-76-2 |
| Product name | D-Glutamic acid 1-tert-butyl ester |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Industrial Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for D-Glutamic acid 1-tert-butyl ester
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk D-Glutamic acid 1-tert-butyl ester Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of D-Glutamic acid 1-tert-butyl ester
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Used as a chiral synthon or intermediate in the synthesis of active pharmaceutical ingredients, such as anticancer or neurological agents | Organic synthesis; commonly employed as a reagent to protect the carboxyl group of glutamic acid in peptide coupling reactions |
| Biochemistry | Used to protect the γ-carboxyl group of glutamic acid during peptide synthesis, preventing side reactions | Solid-phase or solution-phase peptide synthesis; incorporated as an amino acid derivative in condensation reactions |
| Research & Development | Serves as a reagent or building block for synthesizing custom peptides, bioconjugates, or molecular probes | Laboratory-scale chemical synthesis involving deprotection, coupling, and related steps |
Manufacturing Quality Control of D-Glutamic acid 1-tert-butyl ester
| Detection Item | Common Analytical Method | Method Overview |
|---|---|---|
| Assay (Purity) | HPLC-UV | Quantitative determination using reversed-phase HPLC with UV detection at ~205 nm, comparing peak area against a certified reference standard. |
| Enantiomeric Purity | Chiral HPLC | Separation of D- and L-enantiomers on a chiral stationary phase, with quantification based on relative peak areas. |
| Residual Solvents (e.g., tert-butanol, ethyl acetate) | GC-FID | Headspace or direct injection GC with flame ionization detection, calibrated against solvent standards per ICH Q3C. |
| Water Content | Karl Fischer Titration (Coulometric) | Electrochemical titration where iodine is generated in situ to react stoichiometrically with water; measures trace moisture content. |
| Heavy Metals (Pb, Cd, Hg, As) | ICP-MS | Multi-element quantification after acid digestion, using inductively coupled plasma mass spectrometry for sub-ppb sensitivity. |
| Residual Chloride (as Cl⁻) | Ion Chromatography (IC) | Anion exchange separation with conductivity detection, quantifying chloride ion via calibration curve. |
| Melting Point | Capillary Melting Point Apparatus | Thermal transition observed visually or automatically as the solid-to-liquid phase change under controlled heating rate. |
| Specific Optical Rotation | [α]D | Measurement of plane-polarized light rotation in solution at 589 nm (Na D-line), confirming chiral integrity and concentration. |
| Related Substances (Impurities) | HPLC-UV (Forced Degradation Study) | Detection and quantification of structurally related impurities (e.g., D-glutamic acid, diastereomers) using gradient HPLC-UV. |
| Residual Palladium (if Pd-catalyzed synthesis used) | ICP-OES | Quantification after microwave-assisted acid digestion using inductively coupled plasma optical emission spectroscopy. |
| Loss on Drying (LOD) | Gravimetric Thermogravimetry | Mass loss measured after drying under specified temperature/vacuum conditions, indicating volatile content. |
| pH (1% w/v aqueous solution) | pH Meter | Electrochemical measurement of hydrogen ion activity in aqueous suspension using calibrated pH electrode. |
| Particle Size Distribution | Laser Diffraction | Analysis of scattered laser light intensity vs. angle to determine volume-based particle size distribution in dispersed phase. |
| Microbial Limits | Membrane Filtration + Culture | Enumeration of aerobic microorganisms and absence of specified pathogens per USP <61> and <62>. |
Technical Specifications of D-Glutamic acid 1-tert-butyl ester
| Test Item | Specification |
|---|---|
| Appearance | White solid |
| Purity | >=98.0% (GC) |
| Water Content (KF) | <=0.5% |
| Total Impurities | <=2.0% |
| Single Impurity | <=0.5% |
| Optical Rotation | -14.5 to -13.5 deg (c=1, in 1M HCl) |
| Melting Point | 148 to 152 °C |
| Identification (NMR) | Consistent with structure |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Download COA of D-Glutamic acid 1-tert-butyl ester
| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
NMR Spectra of D-Glutamic acid 1-tert-butyl ester
Safety Information of D-Glutamic acid 1-tert-butyl ester
| Pictograms |  |
| Signal Word | Warning |
| Safety Data Sheet | |
Packaging of D-Glutamic acid 1-tert-butyl ester
Industrial D-Glutamic acid 1-tert-butyl ester Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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