China Factory Direct
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| CAS number | 25475-67-6 |
| Product name | ISOQUINOLIN-3-AMINE |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Agricultural GradeMaterial GradeSpecialty Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
Based on current marketvolatility and material availability.
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Key intermediate for antitumor drugs and kinase inhibitors, used in the synthesis of targeted therapies such as BTK inhibitors | Introduces the isoquinolin-3-amine core structure into drug molecules via Suzuki coupling, reductive amination, or cyclization reactions |
| Agrochemicals | Structural modification unit for novel insecticides and fungicides, enhancing the binding affinity of active molecules toward target enzymes | Participates in heterocycle functionalization reactions—e.g., copper-catalyzed Ullmann coupling with haloarenes—to construct nitrogen-containing heterocyclic agrochemical lead compounds |
| Materials Science | Used in the preparation of hole-transport materials for organic light-emitting diodes (OLEDs) and fluorescent sensing materials | Modulates HOMO/LUMO energy levels to optimize charge-carrier transport performance via N-alkylation or condensation with aldehydes to form Schiff bases |
| Detection Item | Common Analytical Method | Method Overview |
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| Assay (Purity) | HPLC-UV | Quantifies main component using reverse-phase chromatography with UV detection at 254 nm, based on peak area comparison against reference standard. |
| Related Substances | HPLC-UV | Separates and quantifies impurities by retention time and peak area relative to main peak using validated gradient method. |
| Residual Solvents | GC-FID | Detects and quantifies volatile organic solvents (e.g., methanol, acetone) via headspace gas chromatography with flame ionization detection. |
| Water Content | Karl Fischer Titration | Determines water by coulometric or volumetric titration using iodine generation in pyridine-free reagent system. |
| Heavy Metals | ICP-MS | Measures trace metal contaminants (e.g., Pb, Cd, Hg) after acid digestion using inductively coupled plasma mass spectrometry. |
| Chloride Impurity | Ion Chromatography | Quantifies chloride ions via suppressed conductivity detection after separation on anion-exchange column. |
| Sulfated Ash | Gravimetric Analysis | Measures inorganic residue after controlled combustion at 700-800 C followed by weighing of residual ash. |
| Melting Point | Capillary Melting Point Apparatus | Determines temperature range at which solid transitions to liquid using calibrated capillary tube method per USP <741>. |
| Appearance | Visual Inspection | Assesses physical state, color, and presence of visible particulates or discoloration under controlled white light. |
| pH (1% w/v aqueous suspension) | pH Meter | Measures hydrogen ion activity in a saturated aqueous suspension using calibrated pH electrode. |
| Loss on Drying | Thermogravimetric Analysis | Quantifies volatile content by weight loss upon heating at 105 C for 2 hours under controlled airflow. |
| Specific Optical Rotation | Polarimetry | Measures chiral purity by determining rotation angle of plane-polarized light through a solution in specified solvent and path length. |
| Test Item | Specification |
|---|---|
| Appearance | Brown solid |
| Purity | >=98.5% (HPLC) |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Water Content (KF) | <=0.5% |
| Melting Point | 128–132°C |
| Identification (NMR) | Consistent with structure |
| Heavy Metals | <=20 ppm |
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| CAS/Product ID | *Required fields | |
| Lot/Batch Number | *Required fields | |
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.