1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile Bulk Supply for Industrial Use
China Factory Direct
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| CAS number | 256376-65-5 |
| Product name | 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbonitrile |
| Stock | Stock readily available; annual supply capacity exceeding 1,000 tons. |
| Grade | Reagent Grade |
| Packaging | 25KG/bag |
| Sample | Test Samples Available (Click to Request Samples) |
| COA | View COA |
| Price | Get Quote |
| Supply Type | Bulk / Contract manufacturing / OEM |
| Shipping | FCL / LCL available |
| Payment Terms | Support FOB \ CIF \ EXW quotations, and accept Letter of Credit (L/C). |
| Manufacturer | Greenrock Chemical(China Factory) |
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Documents We Provide for 256376-65-5
Post-sale: Full documentation is provided.
To request documents, please contact us via email at sales@GRchemical.com.
Bulk 256376-65-5 Supplier from China
17+ years in chemical exports.Fully compliant, reliable supply.Your B2B partner in bulk chemical procurement.
Industrial Applications of 256376-65-5
| Industry | Application | Process |
|---|---|---|
| Pharmaceuticals | Drug intermediate | Used in the synthesis of antitumor compounds via reaction with specific functional groups to yield target products |
| Chemical research | Laboratory reagent | Applied under laboratory conditions to explore synthetic pathways and properties of novel compounds |
Manufacturing Quality Control of 256376-65-5
| Detection Item | Common Testing Methods | Method Overview |
|---|---|---|
| Appearance and Physical Properties | Visual Inspection, Physical Property Measurement | Observe color, state (e.g., white to off-white powder), crystalline form, odor, etc., in compliance with pharmacopoeia or internal company specifications. |
| Melting Point | Capillary Melting Point Method | Determine the melting point range using a standard capillary tube method, comparing with literature values or reference standards to assess purity and polymorphic consistency (typical range: 180–190°C, depending on crystal form). |
| Content Determination (Main Component) | High-Performance Liquid Chromatography (HPLC) | Use a C18 column with gradient elution of water-acetonitrile or methanol-buffer salt system, detected by UV detector (λ = 254 nm). Quantify main component using external standard or internal standard method; typically requires ≥98.0%. |
| Related Substances (Impurity Profile) | HPLC (Gradient Elution) | Use same or optimized HPLC conditions as for content determination to detect process impurities, degradation products, and unreacted raw materials. Detection limit ≤0.1%, individual impurity ≤0.5%, total impurities ≤1.0%, complying with ICH Q3B guidelines. |
| Residual Solvents | Gas Chromatography (GC) | Utilize headspace injection or direct injection GC-FID/MS to detect residual solvents such as methanol, ethanol, acetone, dichloromethane, acetonitrile according to ICH Q3C guidelines, ensuring compliance with specified limits (e.g., acetonitrile ≤410 ppm). |
| Water Content | Karl Fischer Titration (KF) | Determine trace moisture using coulometric or volumetric Karl Fischer reagent, controlling water content ≤0.5% to prevent hydrolysis or polymorphic transformation. |
| Heavy Metal Content | Atomic Absorption Spectroscopy (AAS) or ICP-MS | After sample digestion, detect heavy metals including lead, cadmium, mercury, arsenic, copper, etc., in accordance with ICH Q3D or pharmacopoeial standards (e.g., total heavy metals ≤10 ppm). |
| Fluorine Content (Characteristic Element Confirmation) | Ion Selective Electrode Method / Combustion Ion Chromatography | Determine fluoride ion after oxygen bomb combustion and absorption, or directly analyze via ion chromatography (IC), confirming the presence and quantifying fluorine atoms in the molecule for structural verification and purity control (theoretical F content ≈7.5%). |
| Isomer Check (if applicable) | HPLC-MS / Chiral Chromatography | If stereochemical or positional isomerism risk exists (e.g., 2-fluorobenzyl positional isomers), use chiral columns or high-resolution mass spectrometry to differentiate and ensure no non-target isomer contamination. |
| UV-Visible Absorption Spectroscopy (UV-Vis) | UV-Vis Spectrophotometry | Measure characteristic absorption peaks (e.g., λmax ≈ 260–280 nm) in ethanol or methanol solution for auxiliary identification and concentration estimation, compared with standard spectra. |
| Infrared Spectroscopy (IR) | Fourier Transform Infrared Spectroscopy (FT-IR) | Obtain characteristic functional group absorption peaks (e.g., nitrile ~2240 cm⁻¹, aromatic C=C ~1600 cm⁻¹, C-F ~1200–1250 cm⁻¹) for structural confirmation and batch-to-batch consistency comparison. |
| Nuclear Magnetic Resonance (¹H NMR / ¹³C NMR) | Nuclear Magnetic Resonance Spectroscopy | Dissolve sample in DMSO-d6 or CDCl₃, perform proton and carbon NMR analysis to confirm molecular structure, substitution positions, and purity. Considered the gold standard for structural verification, often used for batch release or dispute resolution of questionable samples. |
| Liquid Chromatography-Mass Spectrometry (LC-MS) | LC-MS Coupling Technology | Used for impurity identification, structural elucidation, and trace-level impurity detection. Obtain [M+H]⁺ or [M-H]⁻ ions under ESI positive/negative mode (theoretical m/z = 256.1), confirming molecular weight and fragmentation patterns. |
| Microbial Limits (if applicable for pharmaceutical intermediates) | Plate Count Method / MPN Method | If used as a pharmaceutical intermediate or precursor for sterile formulations, test for aerobic bacteria count, mold and yeast, and Escherichia coli, meeting pharmacopoeial microbiological limits for non-sterile products (e.g., ≤10³ CFU/g). |
Technical Specifications of 256376-65-5
| Test Item | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | >=98.5% |
| Total Impurities | <=1.5% |
| Single Impurity | <=0.5% |
| Melting Point | 178°C - 182°C |
| Water Content (KF) | <=0.5% |
| Residue on Ignition | <=0.1% |
| Heavy Metals | <=10 ppm |
Specifications vary by industry. Reach out to our technical experts for a COA tailored specifically to your application. Email:selse@GRchemical.com
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Industrial 256376-65-5 Procurement FAQ
1. How do you ensure product quality consistency?
We rely on a mature China-based manufacturing system and implement strict batch control and quality inspection for every shipment. Our production process complies with ISO 9001 standards, and a COA is provided for each batch to ensure consistent and reliable quality.
2. Do you offer competitive pricing for bulk orders?
Yes, as a China-based manufacturer and bulk supplier, we provide tiered pricing based on order volume. We support FOB and CIF quotations, as well as L/C payment terms for large transactions to meet international trade requirements.
3. Can you support large-volume or long-term supply?
We have stable production capacity and a well-established supply chain, enabling continuous bulk supply. We support ton-level and container-level orders, as well as long-term cooperation projects.
4. What is your typical lead time?
For in-stock products, shipment can be arranged within 1–3 days. For bulk packaging or customized orders, lead time depends on the specific quantity and production schedule.
5. What documents do you provide?
We can provide complete documentation upon request, including COA, SDS, TDS, and other compliance certificates, meeting industrial procurement and export requirements.
6. Can you customize product specifications or packaging?
Yes, we support customization of parameters such as purity, impurities, residual solvents, and heavy metals. We also offer various bulk packaging options, including 25kg bags, drums, and IBC tanks, suitable for industrial applications and transportation.
7. What shipping options do you support?
We support both FCL (Full Container Load) and LCL (Less than Container Load) shipments, and can flexibly arrange logistics solutions based on order size to meet bulk chemical export needs.
8. Do you provide technical or application support?
Yes, we provide basic application guidance and technical support based on industry experience to help customers optimize product usage.
9. How do you handle compliance and export regulations?
We are familiar with international trade and export regulations, ensuring all products comply with relevant requirements. We also provide complete documentation to support smooth customs clearance and global delivery.
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